摘要
乳腺癌已经成为全球女性中最普遍的癌症。目前乳腺癌的主要治疗方法包括手术切除、放射治疗、化学疗法、内分泌治疗等,尽管已经被广泛采用,但患者仍然面临脱靶效应和严重的全身不良反应。近年来,基于纳米粒的药物递送系统因其精确的靶向性和相对低毒性而在乳腺癌治疗领域备受瞩目。本文综述了仿生纳米粒的结构,着重介绍了仿生纳米粒的"核壳"结构,包括不同生物膜以及其内部核心结构。我们还探讨了仿生纳米粒子成像技术及其在乳腺癌治疗中的应用。研究结果表明,仿生纳米联合治疗能够有效抑制乳腺癌细胞的生长,并减少乳腺癌的转移。随着纳米技术研究的不断成熟和发展,基于仿生纳米粒子的药物递送系统将推动乳腺癌治疗提升到更高水平,并为改善患者的预后和预防癌症复发提供了希望。
Breast cancer stands as the most commonly diagnosed cancer in women worldwide.Despite the wide adoption of various treatments,including radiotherapy,chemotherapy,surgery,enndocrine therapy,patients continue to grapple with off-target effects and severe systemic side effects.In recent years,nanoparticle-based drug delivery systems have garnered significant attention in the field of novel breast cancer treatment due to their precise targeting ability and relatively low toxicity.This review provided a concise overview of the latest advancements in biomimetic nanoparticles for breast cancer treatment,particularly focusing on the"core-shell"structure which included different biological membranes and their internal core structures.Furthermore,the review elucidated the visualization method for biomimetic nanoparticles and their application in the treatment of breast cancer.Studies had demonstrated that combination of biomiments nanoparticles with other treatments can effectively impede the growth of breast cancer cells and reduce metastasis.With the continuous evolution of nanotechnology in the research field,the biomimetic nanoparticle-based drug delivery system holds the potential to elevate breast cancer treatment to a higher level,offering the possibility of improved prognoses and reduced cancer recurrence.
作者
王文琪
史菁菁
王嘉慧
南丽虹
路红
Wang Wenqi;Shi Jingjing;Wang Jiahui;Nan Lihong;Lu Hong(Department of Breast Imaging,Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy,Tianjin Tianjin’s Clinical Research Center for Cancer Key Laboratory of Breast Cancer Prevention and Therapy,Tianjin Medical University,Ministry of Education,Tianjin 300060,China)
出处
《中华实验外科杂志》
CAS
2024年第4期865-870,共6页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金面上项目(82172025)
天津市医学重点学科(专科)建设项目(TJYXZDXK-009A)。
关键词
仿生纳米药物递送系统
壳核结构
乳腺癌
细胞膜
成像
Biomimetic nanodrug delivery systems
Core-shell structure
Breast cancer
Cell membranes
Imaging
