摘要
磁性氧化铁纳米颗粒在磁共振成像方面的应用,已经在全世界范围内得到了广泛的关注,相关研究也被各国科学家高度重视。目前,磁性氧化铁纳米颗粒正在从早期的基于被动识别的肝部磁共振造影,快速转向基于主动识别的磁共振分子影像应用。本文将围绕磁性氧化铁纳米颗粒的生物体内应用,着重介绍磁性纳米颗粒的制备及其在疾病诊断,尤其是在肿瘤早期影像诊断方面的研究进展。
Magnetic iron oxide nanoparticles have received great attention due to their applications as contrast agents for magnetic resonance imaging（MRI）.Now,in vivo applications of iron oxide nanoparticles are gradually shifting from passive targeting mode,such as liver imaging,to active targeting mode,leading to the emerging of a new multidisciplinary field-Molecular Imaging.This review mainly discusses the synthesis of magnetic iron oxide nanoparticles and their MRI applications,especially in molecular imaging of early tumors.
出处
《生物物理学报》
CAS
CSCD
北大核心
2011年第4期272-288,共17页
Acta Biophysica Sinica
基金
"973"计划项目(2011CB935800)
国家自然科学基金项目(21003135
81090271
20820102035)~~
关键词
磁性氧化铁纳米颗粒
磁共振
分子影像探针
肿瘤
Magnetic iron oxide nanoparticles
Magnetic resonance
Molecular imaging probe
Tumor
