摘要
目的:分析布地奈德联合肺表面活性物质(PS)预防呼吸窘迫综合征早产儿支气管肺发育不良(BPD)的效果。方法:选取2021年5月—2023年5月郯城县第一人民医院收治的呼吸窘迫综合征早产儿90例,依据随机数字表法分为对照组和研究组,各45例。对照组采用PS治疗,研究组采用布地奈德联合PS治疗。比较两组治疗效果。结果:治疗后,研究组动脉血二氧化碳分压(PaCO_(2))低于对照组,动脉血氧分压(PaO_(2))、pH值高于对照组,差异有统计学意义(P<0.05)。研究组BPD发生率显著低于对照组,差异有统计学意义(P<0.05)。研究组使用呼吸机时间、吸氧时间均短于对照组,差异有统计学意义(P<0.05)。研究组并发症发生率为8.88%,低于对照组的24.44%,差异有统计学意义(P<0.05)。结论:布地奈德联合PS治疗呼吸窘迫综合征早产儿的效果较好,能够对BPD进行有效预防,可改善患儿血气指标,降低并发症发生率,促进其早日康复。
Objective:To analyze the effect of budesonide combined with pulmonary surfactant(PS)on preventing bronchopulmonary dysplasia(BPD)in premature infants with respiratory distress syndrome.Methods:Ninety preterm infants with respiratory distress syndrome treated in Tancheng County First People's Hospital from May 2021 to May 2023 were selected and divided into control group and study group according to random number table method,with forty-five cases in each group.The control group was treated with PS,and the study group was treated with budesonide combined with PS.The therapeutic effect of the two groups was compared.Results:After treatment,the partial blood pressure of carbon dioxide(PaCO_(2))in the study group was lower than that in the control group,and the partial blood pressure of oxygen(PaO_(2))and PH value were higher than that in the control group,the differences were statistically significant(P<0.05);the incidence of BPD in the study group was significantly lower than that in the control group,with statistical significance(P<0.05);the time of ventilator use and oxygen inhalation in the study group were shorter than those in the control group,and the difference was statistically significant(P<0.05);the incidence of complications in the study group was 8.88%,lower than 24.44%in the control group,and the difference was statistically significant(P<0.05).Conclusion:Budesonide combined with PS has a good effect on the treatment of premature infants with respiratory distress syndrome,can effectively prevent BPD,improve blood gas indexes,reduce the incidence of complications,and promote their early recovery.
作者
高丽娟
Gao Lijuan(Tancheng County First People's Hospital,Linyi 276100,Shandong Province,China)
出处
《中外医药研究》
2024年第8期75-77,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
早产儿
呼吸窘迫综合征
布地奈德
肺表面活性物质
Premature infants
Respiratory distress syndrome
Budesonide
Pulmonary surfactant
