摘要
目的:探讨缺血性脑卒中(ICS)患者颈动脉粥样硬化(CAS)与血压变异性(BPV)的相关性。方法:选取2020年3月—2023年3月苏州市相城区第二人民医院神经内科收治的ICS患者100例为研究对象。依据颈动脉内膜中层厚度(cIMT)分为单纯ICS组(27例)、ICS颈动脉内膜增厚组(41例)和ICS颈动脉斑块形成组(32例)。监测患者24 h动态血压,比较三组cIMT、BPV指标[24 h收缩压标准差(24 h-SSD)、24 h舒张压标准差(24 h-DSD)、日间收缩压标准差(d-SSD)、日间舒张压标准差(d-DSD)、夜间收缩压标准差(n-SSD)、夜间舒张压标准差(n-DSD)],分析cIMT与BPV指标的相关性。结果:三组cIMT、24 h-SSD、d-SSD、n-SSD、24 h-DSD、n-DSD比较,差异有统计学意义(P<0.05);三组d-DSD比较,差异无统计学意义(P>0.05);ICS颈动脉内膜增厚组cIMT、n-SSD,ICS颈动脉斑块形成组cIMT、24 h-SSD、d-SSD、n-SSD、24 h-DSD、n-DSD高于单纯ICS组,差异有统计学意义(P<0.05);ICS颈动脉斑块形成组cIMT、24 h-SSD、d-SSD、n-SSD高于ICS颈动脉内膜增厚组,差异有统计学意义(P<0.05)。经Spearman相关性分析,cIMT与24 h-SSD、d-SSD、n-SSD呈正相关(r=0.315,P=0.004;r=0.296,P=0.007;r=0.240,P=0.011),与24 h-DSD、d-DSD、n-DSD无相关性(P>0.05)。结论:ICS患者CAS与收缩压变异性存在相关性,收缩压变异性增加可能参与了ICS患者CAS的发生和进展过程。
Objective:To investigate the relationship between carotid atherosclerosis(CAS)and blood pressure variability(BPV)in patients with ischemic stroke(ICS).Methods:A total of 100 ICS patients were selected as the study objects at the Department of Neurology of the Second People's Hospital of Xiangcheng District of Suzhou from March 2020 to March 2023.The patients were divided into ICS group(27 cases),ICS group with carotid intima thickened(41 cases)and ICS group with carotid plaque formation(32 cases)according to carotid intimesia thickness(cIMT).24 h ambulatory blood pressure was monitored.The cIMT and BPV indexes[24 h standard deviation of systolic blood pressure(24 h-SSD),24 h standard deviation of diastolic blood pressure(24 h-DSD),standard deviation of daytime systolic blood pressure(d-SSD),standard deviation of daytime diastolic blood pressure(d-DSD),standard deviation of nighttime systolic blood pressure(n-SSD),standard deviation of nighttime diastolic blood pressure(n-DSD)]were compared among the three groups,and the correlation between cIMT and BPV index was analyzed.Results:There were significant differences in cIMT,C24 h-SSD,d-SSD,n-SSD,24 h-DSD and n-DSD among the three groups(P<0.05).There was no significant difference in d-DSD among the three groups(P>0.05);cIMT,n-SSD in ICS carotid intima thickening group and cIMT,24 h-SSD,d-SSD,n-SSD,24 h-DSD,n-DSD in ICS carotid plaque formation group were higher than those in ICS group,and the difference was statistically significant(P<0.05).cIMT,24 h-SSD,d-SSD and n-SSD in ICS carotid plaque formation group were higher than those in ICS carotid intima thickening group,and the difference was statistically significant(P<0.05).Spearman correlation analysis showed that cIMT was positively correlated with 24 h-SSD,d-SSD and n-SSD(r=0.315,P=0.004;r=0.296,P=0.007;r=0.240,P=0.011),there was no correlation with 24 h-DSD,d-DSD,n-DSD(P>0.05).Conclusion:There is a correlation between CAS and systolic blood pressure variability in ICS patients,and the increase of systolic blood
作者
陆晓莲
赵桂森
邹鄞
毛炜涛
Lu Xiaolian;Zhao Guisen;Zou Yin;Mao Weitao(Department of Neurology,The Second People's Hospital of Xiangcheng District of Suzhou,Suzhou 215143,Jiangsu Province,China)
出处
《中外医药研究》
2024年第9期30-32,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
缺血性脑卒中
颈动脉粥样硬化
血压变异性
相关性
Ischemic stroke
Carotid atherosclerosis
Blood pressure variability
Correlation
