摘要
目的 研究血浆致动脉粥样硬化指数(AIP)是否为绝经后高血压患者颈动脉硬化的独立危险因素。方法 选取2019年6月至2021年6月因高血压收住新疆医科大学第五附属医院的绝经后女性高血压患者303例进行回顾性研究,以颈部血管超声结果提示有无颈动脉斑块进行分组,分为绝经后高血压合并颈动脉硬化组(观察组,n=187)、单纯绝经后高血压组(对照组,n=115),检测并比较2组患者的一般资料,以及总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、脂蛋白a、血清肌酐(SCr)、血尿素氮(BUN)、血尿酸(SUA)、胱抑素C(CysC)、同型半胱氨酸(Hcy)、空腹血糖(FBG)等指标,并计算血浆AIP。使用多因素logistic回归方法分析AIP及其他传统风险因素对颈动脉硬化的影响。结果 观察组患者的年龄、腰围、平均舒张压、TC、TG、AIP、LDL-C、脂蛋白a、FBG、有糖尿病史比例明显高于对照组,差异有统计学意义(P<0.05)。校正AIP(aAIP)与各变量进行Pearson或Spearman相关因素分析,结果显示,aAIP与腰围、TC、TG、LDL-C、SUA、FBG、糖尿病史呈正相关(P<0.05),与平均舒张压、HDL-C、直接胆红素、Hcy呈负相关(P<0.05)。多因素logistic回归分析显示,观察组患者年龄[OR=1.198,95%CI(1.142,1.257),P<0.05)、LDL-C[OR=1.508,95%CI(1.048,2.169),P<0.05]和aAIP[OR=3.938,95%CI(1.142,1.257),P<0.05]是绝经后高血压患者颈动脉硬化的独立风险因素;aAIP受试者工作特征(ROC)曲线下面积为0.600[95%CI(0.533,0.666)],当aAIP截断值为2.04时,其诊断效能最高,灵敏度为49.7%,特异度为69.6%。结论 对于绝经后高血压患者,AIP是颈动脉硬化的独立危险因素,aAIP>2.04可作为诊断绝经后高血压患者颈动脉硬化的敏感指标。
Objective To investigate whether arteriosclerosis index of plasma(AIP)is an independent risk factor for carotid atherosclerosis in the patients with postmenopausal hypertension.Methods A retrospective study was conducted in 303 patients with postmenopausal hypertension treated in the Fifth Affiliated Hospital of Xinjiang Medical University from June 2019 to June 2021.According to whether the cervical vascular ultrasound results indicating carotid plaque,the patients were divided into the postmenopausal hypertension combined with carotid atherosclerosis group(observation group,n=187)and simple postmenopausal hypertension group(control group,n=115).The general data,total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL-C),low density lipoprotein(LDL-C),lipoprotein(a)[Lp(a)],serum creatinine(SCr),blood urea nitrogen(BUN),uric acid(UA),cystatin C(CysC),homocysteine(Hcy),fasting blood glucose(FBG)were detected and compared,and the atherogenic index of plasma(AIP)was calculated.The multivariate logistic regression method was used to analyze the influence of AIP and other traditional risk factors on carotid atherosclerosis.Results The age,waist circumference,mean diastolic blood pressure,TC,TG,AIP,LDL-C,Lp(a),FBG and diabetic history proportion in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The Pearson or Spearman correlation factors analysis was performed on the corrected AIP and various variables,and its results showed that aAIP was positively correlated with the waist circumference,TC,TG,LDL-C,uric acid,FBG and diabetic history(P<0.05),and negatively correlated with mean diastolic blood pressure,HDL-C,direct bilirubin and Hcy(P<0.05).The multivariate Logistic regression analysis showed that the age[OR=1.198,95%CI(1.142,1.257),P<0.05],LDL-C[OR=1.508,95%CI(1.048,2.169),P<0.05]and aAIP[OR=3.938,95%CI(1.142,1.257),P<0.05]were the independent risk factors.The area under the receiver operating characteristic(ROC)curv
作者
王雪华
祖可来·艾力江
李红建
吕忠英
邹婷
托合提古丽·亚森
米日班·买买提明
WANG Xuehua;ZUKELAI·Ailijiang;LI Hongjian;LYU Zhongying;ZOU Ting;TUOHETIGULI·Yasen;MIRIBAN·Maimaitiming(Graduate School of Xinjiang Medical University,Urumqi,Xinjiang 830011,China;Department of Hypertension,Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830011,China)
出处
《重庆医学》
CAS
2023年第8期1128-1132,1136,共6页
Chongqing medicine
基金
国家重点研发计划项目(2018YFC1311503)。
关键词
血浆致动脉硬化指数
绝经后高血压
颈动脉硬化
诊断价值
arteriosclerosis index of plasma
postmenopausal hypertension
carotid atherosclerosis
diagnostic value
