摘要
半胱氨酸白三烯(CysLT)是免疫细胞合成和分泌的炎性介质,与细胞膜上的受体结合发挥生物学效应,参与多种过敏性疾病的发病。抗白三烯药物有两类:CysLT1受体拮抗剂(LTRA)和白三烯合成抑制剂,前者与CysLT1受体结合,从而干扰过敏性炎症的发生。LTRA在儿童过敏性疾病的治疗中广泛应用,但仍存在质疑与挑战。因此,中国鼻病研究协作组召集国内中青年鼻科专家,制订了LTRA治疗儿童变应性鼻炎专家共识,旨在指导儿童变应性鼻炎临床诊疗工作。目前国内外指南均推荐LTRA作为儿童变应性鼻炎治疗的一线药物。儿童对孟鲁司特一般耐受性良好,总体不良反应发生率与安慰剂相似,对神经精神影响的研究尚无统一意见,临床医师应意识到神经精神事件的潜在风险,在开具相应处方时注意权衡利弊。
Cysteine leukotriene(CysLT)is an inflammatory medium synthesized and secreted by immune cells.It is involved in many allergic diseases by binding with cell membrane receptors to exert biological effects.There are two classes of anti-leukotriene drugs:CysLT1 receptor antagonists(LTRA),which bind to CysLT1R and thus interfere with the occurrence of allergic inflammation,and leukotriene synthesis inhibitors.LTRA has been widely used in the treatment of allergic diseases in children,but there are still concerns and challenges.Therefore,the Chinese Rhinopathy Research Collaboration Group convened young and middle-aged rhinology experts in China to develop an expert consensus and guide the treatment of allergic rhinitis in children with LTRA.At present,both domestic and foreign guidelines recommend LTRA as the first-line medicine for the treatment of allergic rhinitis in children.Montelukast is generally well tolerated in children,and the overall incidence of adverse reactions is similar to placebo.There is no consensus on the neuropsychiatric effects of Montelukast.Clinicians should be aware of the potential risk of neuropsychiatric events,and consider benefits and risks when prescribing LTRA.
作者
刘文龙
罗茜
曾清香
杨钦泰
邱前辉
徐睿
孙悦奇
杨贵
唐隽
洪海裕
许元腾
石照辉
魏欣
王天生
孟娟
杨玉成
王英
娄鸿飞
孟粹达
叶菁
张立强
杨艳莉
安云芳
陆美萍
曾明
王向东
陈建军
雍军
余少卿
张维天
孙亚男
张天虹
孙娜
李幼瑾
刘翔
李健
左可军
罗向前
王洪田
许昱
喻国冻
付勇
叶惠平
李勇
许成利
李华斌
中国鼻病研究协作组
LIU Wenlong;LUO Xi;ZENG Qingxiang;YANG Qintai;QIU Qianhui;XU Rui;SUN Yueqi;YANG Gui;TANG Jun;HONG Haiyu;XU Yuanteng;SHI Zhaohui;WEI Xin;WANG Tiansheng;MENG Juan;YANG Yucheng;WANG Ying;LOU Hongfei;MENG Cuida;YE Jing;ZHANG Liqiang;YANG Yanli;AN Yunfang;LU Meiping;ZENG Ming;WANG Xiangdong;CHEN Jianjun;YONG Jun;YU Shaoqing;ZHANG Weitian;SUN Yanan;ZHANG Tianhong;SUN Na;LI Youjin;LIU Xiang;LI Jian;ZUO Kejun;LUO Xiangqian;WANG Hongtian;XU Yu;YU Guodong;FU Yong;YE Huiping;LI Yong;XU Chengli;LI Huabin;Chinese Rhinopathy Research Cooperation Group(Department of Otorhinolaryngology Head and Neck Surgery,Guangzhou Women and Children’s Medical Center,Guangzhou 510623,China;Department of Otorhinolaryngology Head and Neck Surgery&Department of Allergy,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China;Department of Otorhinolaryngology Head and Neck Surgery,Guangdong Provincial People’s Hospital,Guangzhou 510080,China;Allergy Department of Otorhinolaryngology Hospital,the First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China;Department of Otorhinolaryngology,the 7th Affiliated Hospital,Sun Yat-sen University,Shenzhen 518107,China;Department of Otorhinolaryngology,the Central Hospital of Shenzhen Longgang District,Shenzhen 518116,China;Department of Otorhinolaryngology Head Neck and Surgery,the First People’s Hospital of Foshan,Foshan 520800,China;Department of Otorhinolaryngology,the 5th Affiliated Hospital,Sun Yat-sen University,Zhuhai 519000,China;Department of Otorhinolaryngology Head Neck and Surgery,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350004,China;Hainan General Hospital,Hainan Affiliated Hospital of Hainan Medical University,Haikou 570311,China;Department of Otorhinolaryngology Head and Neck Surgery,Third Xiangya Hospital,Central South University,Changsha 410013,China;Department of Otorhinolaryngology Head and Neck Surgery,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Otorhinolaryngology Head and Neck Surgery,th
出处
《中国眼耳鼻喉科杂志》
2024年第3期161-169,共9页
Chinese Journal of Ophthalmology and Otorhinolaryngology
基金
国家重点研发计划(2022YFC2504100)
国家自然科学基金(81970864、82171104、82271139、81970850、82271138、81725004、81970861、82271142、82371113、82171104)
国家自然科学基金青年基金(82101201)
广东省自然科学基金(2022A1515012617)。
关键词
白三烯受体拮抗剂
儿童
变应性鼻炎
Leukotriene receptor antagonist
Child
Allergic rhinitis
