摘要
目的 系统评价中医针药联合治疗薄型子宫内膜不孕症的临床疗效。方法 检索知网、万方、维普等数据库,时间限定为自入库至2021年7月,检索内容为针灸联合中药治疗薄型子宫内膜不孕症的随机对照试验(RCT),筛选文献并进行质量评价后,采用Rev Man 5.3软件进行Meta分析。结果 共纳入9项RCTs,共862例薄型子宫内膜不孕症患者。Meta分析显示:与西药治疗相比,针药联合使用在增加子宫内膜厚度[MD=1.65,95%CI(1.42,1.87),Z=14.33(P<0.0000 1)]、降低子宫动脉搏动指数(PI)[MD=-0.10,95%CI(-0.13,-0.07),Z=7.48(P<0.0000 1)]、子宫动脉阻力指数(RI)[MD=-0.05,95%CI(-0.07,-0.04),Z=9.48(P<0.0000 1)]、增加A型子宫内膜比例[RR=1.64,95%CI(1.34,2.00),Z=4.87(P<0.0000 1)]、提高妊娠率[RR=1.62,95%CI(1.37,1.93),Z=5.53(P<0.0000 1)]等方面,差异具有统计学意义。结论 针药联合治疗薄型子宫内膜不孕症比西药治疗具有更好的临床效果,但由于纳入文献质量偏低,该结论还需进一步验证。
Objective To evaluate the clinical effect of acupuncture combined with traditional Chinese herbal medicine on thin endometrial infertility.Methods A randomized controlled trial(RCT)of acupuncture combined with traditional Chinese herbal medicine in the treatment of thin endometrial infertility was searched from CNKI,Wanfang,VIP and other databases from the time of entry to July 2021.After literature selection and quality evaluation,meta-analysis was performed using Rev Man 5.3 software.Results 862 patients with thin endometrial infertility were included in 9 RCTs.Meta-analysis showed that:Compared with western medicine,acupuncture combined with traditional Chinese herbal medicine increased endometrial thickness[MD=1.65,95%CI(1.42,1.87),Z=14.33(P<0.00001)]and decreased uterine artery pulse index(PI)[MD=-0.10,95%CI(-0.13,-0.07),Z=7.48(P<0.00001)],uterine artery resistance index(RI)[MD=-0.05,95%CI(-0.07,-0.04),Z=9.48(P<0.00001)],increased the proportion of type A endometrium[RR=1.64,95%CI(1.34,2.00,Z-4.87(P<0.00001)]and increased pregnancy rate[RR=1.62,95%CI(1.37,1.93),Z=5.53(P<0.00001)l,the differences were statistically significant(P<0.05).Conclusion The combination of acupuncture and traditional Chinese herbal medicine in the treatment of thin endometrial infertility has better clinical effect than that of western medicine.However,due to the low quality of the included literature,this conclusion needs further verification.
作者
董婷
路芳
Dong Ting;Lu Fang(Department of Obstetrics and Gynecology,Zibo Integrated Traditional Chinese and Western Medicine Hospital,Zibo 255020,China)
出处
《实用妇科内分泌电子杂志》
2024年第6期1-6,共6页
Electronic Journal of Practical Gynecological Endocrinology
基金
山东省中医药科技项目(编号2021M108)。
关键词
薄型子宫内膜
不孕症
针药结合
META分析
Thin endometrium
Infertility
Combination of acupuncture and traditional Chinese herbal medicine
Metaanalysis
