摘要
目的探析辅助性T细胞(T helper cell,Th)9及相关细胞因子白介素9(interleukin 9,IL-9)与子宫内膜癌(endometrial cancer,EC)手术患者预后的关系。方法选择2017年3月至2020年2月浙江省丽水市中心医院行手术治疗的136例EC患者作为研究对象,术前检测Th9及其相关细胞因子IL-9、肿瘤标志物等,并记录一般临床资料。全部患者治疗出院后接受为期3年的随访,随访截止时间为2023年2月,以随访期间生存情况作为手术预后的评估标准,并将患者以此分为生存组和病死组。采用Cox回归分析Th9细胞及其相关细胞因子IL-9水平与EC手术患者生存预后的关系。结果收治的136例EC患者中,其中110例患者随访期间生存,生存率为80.88%。病死组Ⅱ期比例多于生存组,Th9细胞水平、血清CA199和IL-9水平均高于生存组(P<0.05)。构建Cox回归模型结果显示,Ⅱ期、CA199、Th9细胞及IL-9水平升高导致EC手术患者生存预后风险增加(P<0.05)。绘制ROC曲线,Th9细胞和IL-9单独及联合对EC手术患者生存预后的预测价值均良好,且以联合预测的价值最好。低Th9组和低IL-9组的病死率高于高Th9细胞组和高IL-9组,差异均有统计学意义(Log rankχ^(2)=44.140、27.289,P均<0.001)。结论Th9及其细胞因子IL-9与EC手术患者生存预后存在相关性,二者水平升高则提示患者生存预后不良风险高,二者未来可能成为预测患者生存预后的有效手段。
Objective To analyze the relationship between T helper cell(T helper cell,Th)9 and interleukin 9(Interleukin 9,IL-9)and the prognosis of patients with endometrial cancer(EC)after surgery.Methods A total of 136EC patients who underwent surgical treatment in Lishui Municipal Central Hospital from March 2017 to February 2020were selected as the research subjects.Th9,its related cytokine IL-9 and tumor markers were detected before surgery,and general clinical data were recorded.All patients were followed up for 3 years after treatment and discharge.The follow-up period ended in February 2023,the patients were divided into survival group and death group based on the survival status during follow-up.Cox regression was used to analyze the relationship between the level of Th9 and its related cytokine IL-9 and the survival prognosis of patients undergoing EC surgery.Results From March 2017 to February 2020,a total of 136 EC patients were included,of which 110 patients survived during the follow-up period,with a survival rate of 80.88%.The proportion of stageⅡin the death group was higher than that in the survival group,and the levels of Th9 cells,serum CA199 and IL-9 were higher than those in the survival group(P<0.05).The results of Cox regression model showed that the increased level of stageⅡ,CA199,Th9 cells and IL-9 led to an increased the risk of survival and prognosis in EC patients(P<0.05).ROC curve showed that Th9 cells and IL-9 alone and in combination had good predictive value for survival and prognosis of patients undergoing EC surgery,and the combined predictive value was the best.The mortality of low Th9 group and low IL-9 group was higher than that of high Th9 cell group and high IL-9 group,and the difference was statistically significant(log rankχ^(2)=44.140,27.289,P<0.001).Conclusion Th9 and its cytokine IL-9 are correlated with the survival prognosis of patients after EC surgery,and the increased levels of both indicate a high risk of poor survival prognosis of patients,and both may become effective
作者
孙聪
黄玲聪
SUN Cong;HUANG Lingcong(Department of Obstetrics and Gynecology,Lishui Municipal Central Hospital,Lishui Zhejiang 323000,China)
出处
《中国妇产科临床杂志》
CSCD
北大核心
2024年第3期249-252,共4页
Chinese Journal of Clinical Obstetrics and Gynecology
基金
丽水市科技计划项目(2019SJZC28)。
