摘要
目的 观察地榆升白胶囊对结直肠癌卡培他滨、奥沙利铂化疗患者骨髓抑制的影响。方法将我院80例结直肠癌患者随机分为治疗组与对照组各40例。对照组采用卡培他滨、奥沙利铂化疗,治疗组在对照组化疗基础上口服地榆升白胶囊。比较两组白细胞、中性粒细胞、血小板和血红蛋白异常比例;比较外周血水平(白细胞、中性粒细胞、血小板和血红蛋白计数);比较重组人粒细胞集落刺激因子(G-CSF)应用率;比较治疗前后肝肾功能指标血尿素氮(BUN)、血肌酐(CREA)、谷草转氨酶(AST)、谷丙转氨酶(ALT)及Karnofsky功能状态(KPS)评分。结果 治疗后,治疗组白细胞和中性粒细胞计数异常比例低于对照组(P<0.05),两组血小板、血红蛋白计数异常比例差异无统计学意义(P>0.05);两组骨髓抑制指标低于治疗前,治疗组骨髓抑制指标高于对照组(P<0.05);治疗组G-CSF应用率低于对照组(P<0.05);两组肝肾功能指标高于治疗前,治疗组肝肾功能指标低于对照组(P<0.05);两组KPS评分高于治疗前,治疗组KPS评分高于对照组(P<0.05)。结论 地榆升白胶囊有效预防结直肠癌卡培他滨、奥沙利铂化疗患者的骨髓抑制,减少G-CSF应用,保护肝肾功能和免疫功能,改善健康状况。
Objective To observe the effect of Diyu Shengbai Capsules on bone marrow suppression in patients with colorectal cancer treated with capecitabine and oxaliplatin.Methods Eighty patients with colorectal cancer were randomly divided into treatment group and control group,40 cases each.Control group was treated with capecitabine and oxaliplatin chemotherapy,while treatment group was treated with oral Diyu Shengbai Capsules on the basis of control group.Abnormal ratios of white blood cells,neutrophils,platelets,and hemoglobin,peripheral blood levels(white blood cells,neutrophils,platelets,and hemoglobin counts),the application rate of recombinant human granulocyte colony-stimulating factor(G-CSF),liver and kidney function indexes blood urea nitrogen(BUN),serum creatinine(CREA),aspartate aminotransferase(AST),alanine aminotransferase(ALT)and Karnofsky functional status(KPS)scores in the two groups before and after treatment were compared.Results After treatment,the proportion of abnormal white blood cell and neutrophil counts in treatment group was lower than control group(P<0.05);there was no significant difference in the proportion of abnormal hemoglobin count(P>0.05);the myelosuppressive index of both groups was lower than that before treatment,the bone marrow suppression index of treatment group was higher than that of control group(P<0.05);the application rate of G-CSF in treatment group was lower than that of control group(P<0.05);the liver and kidney function indexes of both groups were higher than those before treatment,and were lower in treatment group than control group(P<0.05);the KPS score of both groups was higher than that before treatment,and was higher in treatment group than control group(P<0.05).Conclusion Diyu Shengbai Capsules can effectively prevent bone marrow suppression,reduce the application of G-CSF,protect liver and kidney function and immune function,and improve health status in patients with colorectal cancer treated with capecitabine and oxaliplatin chemotherapy.
作者
邱朝亮
朱峰博
戴基浩
曾斌芳
QIU Chao-liang;ZHU Feng-bo;DAI Ji-hao;ZENG Bin-fang(Mingguang People's Hospital,Mingguang 239400;School of TCM,Xinjiang Medical University,Urumqi 830017)
出处
《湖北中医药大学学报》
2024年第2期14-17,共4页
Journal of Hubei University of Chinese Medicine
基金
新疆维吾尔自治区区域协同创新专项(上海合作组织科技伙伴计划及国际科技合作计划)项目(项目编号:2022E01008)。
关键词
结直肠癌
卡培他滨
奥沙利铂
地榆升白胶囊
骨髓抑制
Colorectal cancer
Capecitabine
Oxaliplatin
Diyu Shengbai Capsules
Bone marrow suppression
