摘要
【目的】探讨加味六君子汤改善结直肠癌术后化疗不良反应的临床疗效。【方法】将62例脾虚痰湿型结直肠癌术后化疗患者随机分为治疗组和对照组,每组各31例。对照组仅给予基础化疗方案(FoLFox方案)治疗,治疗组在对照组的基础上配合加味六君子汤治疗,14 d为1个治疗周期,共观察4个周期。观察2组患者治疗前后Karnofsky功能状态评分(KPS)、中医证候积分以及癌胚抗原(CEA)和糖类抗原(CA-199)等肿瘤标志物的变化情况,并评价2组患者的中医证候疗效和安全性。【结果】(1)中医证候疗效方面:治疗4个化疗周期后,治疗组的总有效率为93.55%(29/31),对照组为83.87%(26/31);组间比较(秩和检验),治疗组的中医证候疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)量表评分方面:治疗后,2组患者的KPS评分和中医证候积分均较治疗前明显改善(P<0.05或P<0.01),且治疗组在改善KPS评分和中医证候积分方面均明显优于对照组,组间治疗后及差值比较,差异均有统计学意义(P<0.05)。(3)肿瘤标志物方面:治疗后,2组患者的CEA、CA-199水平均无显著性变化(P>0.05),组间治疗后及差值比较,差异也均无统计学意义(P>0.05)。(4)安全性方面:治疗过程中,治疗组的骨髓抑制的各项不良反应发生率均较对照组低,但组间比较,差异均无统计学意义(P>0.05)。【结论】加味六君子汤可以有效减轻脾虚痰湿型结直肠癌术后化疗患者不良反应,改善患者临床症状,提高患者生活质量,疗效显著。
Objective To investigate the clinical efficacy of modified Liujunzi Decoction in improving the chemotherapy-induced adverse reactions in postoperative patients with colorectal cancer. Methods Sixty-two patients with post-operative chemotherapy for colorectal cancer with spleen deficiency and phlegm-damp syndrome were randomly divided into the treatment group and the control group,with 31 patients in each group. The control group was only given the basic chemotherapy of FOLFOX regimen,while the treatment group was treated with modified Liujunzi Decoction together with the chemotherapy of FOLFOX regimen. Treatment of 14 days constituted one cycle,and both groups were treated for 4 cycles. The changes in Karnofsky Performance Status(KPS)score,traditional Chinese medicine(TCM)syndrome score and tumor markers of carcinoembryonic antigen(CEA)and carbohydrate antigen(CA-199)in the two groups were observed before and after treatment. Moreover,the TCM syndrome efficacy and clinical safety in the two groups were also evaluated. Results(1)After 4 cycles of chemotherapy,the overall effective rate for TCM syndrome efficacy of the treatment group was 93.55%(29/31) and that of the control group was 83.87%(26/31). The intergroup comparison tested by rank sum test showed that the efficacy of TCM syndrome in the treatment group was significantly superior to that in the control group,and the difference was statistically significant(P<0.05).(2)After treatment,the KPS scores and TCM syndrome scores of the two groups were significantly improved compared with those before treatment(P<0.05 or P<0.01),and the treatment group had stronger effect on improving KPS score and TCM syndrome score than the control group.Statistically significant difference was shown in the post-treatment scores and in the pre-and post-treatment difference of the scores between the two groups(P<0.05).(3)After treatment,there were no significant changes in CEA and CA-199 levels in the two groups(P>0.05),and the differences in post-treatment CEA and CA-199 levels a
作者
汤恒电
王炜
TANG Heng-Dian;WANG Wei(The Fifth Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;Guangdong Second Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine,Guangzhou 510095 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2023年第3期596-602,共7页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
加味六君子汤
结直肠癌术后
化疗
脾虚痰湿
不良反应
生活质量
modified Liujunzi Decoction
postoperative colorectal cancer
chemotherapy
spleen deficiency and phlegm-damp syndrome
adverse reactions
quality of life
