摘要
目的 以社区人群为研究对象,探讨中医体质对糖代谢异常进展的影响。方法 纳入2019—2021年参加社区糖尿病筛查并具有基线及第二年随访两次完整的体检资料的社区居民393例。依据其口服葡萄糖耐量试验结果,分为糖代谢异常进展组和非进展组,以倾向性评分匹配功能进行1∶2匹配。采集两组基线时糖尿病相关影响因素,对两组人群进行中医体质判定,比较两组人群的影响因素及中医体质差异,应用Logistic回归方法分析糖代谢异常进展的危险因素。结果 最终纳入进展组131例,非进展组262例。进展组高脂血症病史、血糖升高史、痰湿质、血瘀质占比均高于非进展组(P<0.05或P<0.01)。单因素Logistic回归分析显示,高脂血症病史(P=0.011)、血糖升高史(P<0.001)、糖尿病家族史(P<0.001)、阴虚质(P=0.047)、痰湿质(P=0.011)、血瘀质(P=0.008)是糖代谢异常进展的危险因素。多因素Logistic回归分析显示,血糖升高史(P<0.001)、阴虚质(P=0.026)、血瘀质(P=0.032)是糖代谢异常进展的独立危险因素。结论 患者既往血糖升高史以及中医体质中阴虚质、血瘀质与糖代谢异常进展存在相关性,可能是糖代谢异常进展的危险因素。
Objective To investigate the role of traditional Chinese medicine(TCM)constitution in the progression of abnormal glucose metabolism among community population.Methods A total of 393 community residents who participated in community diabetes screening from 2019 to 2021 and had complete physical examination data at baseline and at the 2nd year follow-up were selected.According to the results of glucose tolerance tests,community residents were divided into the abnormal glucose metabolism progression group and non-progression group,and were matched at the ratio of 1∶2 using the propensity score matching.The influencing factors related to diabetes at baseline were collected for both groups.The traditional Chinese medicine constitution was determined among population in two groups.The differences of influencing factors and traditional Chinese medicine constitution between the two groups were compared.Logistic regression analysis was used to analyze the risk factors for the progression of abnormal glucose metabolism.Results Finally,131 patients were included in the progression group and 262 patients in the non-progression group.Compared to the non-progression group,the progression group had significantly higher proportion of hyperlipidemia history,hyperglycemia history,phlegm-dampness constitution,and blood stasis constitution(P<0.05 or P<0.01).Univariate logistic regression analysis revealed that the history of hyperlipidemia(P=0.011),history of hyperglycemia(P<0.001),the family history of diabetes(P<0.001),yin-deficiency constitution(P=0.047),phlegm-dampness constitution(P=0.011)and blood-stasis constitution(P=0.008)were risk factors for the progression of abnormal glucose metabolism.Multivariate logistic regression analysis indicated that the history of hyperglycemia(P<0.001),yin-deficiency constitution(P=0.026)and blood-stasis constitution(P=0.032)were independent risk factors for the progression of abnormal glucose metabolism.Conclusion The history of hyperglycemia,yin-deficiency constitution and blood-stasis co
作者
黄慧
赵慧敏
许嘉慧
陈清光
陆灏
HUANG Hui;ZHAO Huimin;XU Jiahui;CHEN Qingguang;LU Hao(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,201203)
出处
《中医杂志》
CSCD
北大核心
2024年第9期928-933,共6页
Journal of Traditional Chinese Medicine
基金
上海市进一步加快中医药传承创新发展三年行动计划[ZY(2021-2023)-0302]
上海市临床重点专科建设项目(中医专业)(shslczdzk05401)
上海市中医临床重点实验室项目(20DZ2272200)。
关键词
糖代谢异常
中医体质
危险因素
病例对照研究
abnormal glucose metabolism
traditional Chinese medicine constitution
risk factors
case-control study
