摘要
目的:研究负压创面疗法(negative pressure wound therapy,NPWT)联合银离子水凝胶敷料对糖尿病足溃疡(diabetic foot ulcer,DFU)患者的影响。方法:选取2019年3月—2023年4月首都医科大学石景山教学医院收治的80例DFU患者为试验对象。根据电脑编号奇偶数字法随机将其分为联合组(n=40)及敷料组(n=40)。敷料组给予银离子水凝胶敷料治疗,联合组在敷料组的基础上给予NPWT治疗。比较两组相关指标,治疗前及治疗28 d后踝肱指数(ankle-brachial index,ABI)、血管新生指标、神经传导速度。结果:联合组创面愈合时间及住院天数均短于敷料组,换药次数少于敷料组,差异有统计学意义(P<0.05)。治疗28 d后,两组ABI升高,联合组ABI高于敷料组,差异有统计学意义(P<0.05)。治疗28 d后,两组血管内皮生长因子(vascular endothelial growth factor,VEGF)、碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)、胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)均高于治疗前,内皮抑素(endostatin,ES)低于治疗前,联合组VEGF、bFGF、IGF-1均高于敷料组,ES低于敷料组,差异有统计学意义(P<0.05)。治疗28 d后,两组腓总神经、正中神经感觉神经传导速度(sensory nerve conduction velocity,SCV)与运动神经传导速度(motor nerve conduction velocity,MCV)均升高,联合组腓总神经、正中神经SCV、MCV均高于敷料组,差异有统计学意义(P<0.05)。结论:NPWT联合银离子水凝胶敷料可促进DFU患者的创面愈合,同时可促进血管新生,改善神经传导速度。
Objective:To investigate the effects of negative pressure wound therapy(NPWT)combined with silver ion hydrogel dressing on diabetic foot ulcer(DFU)patients.Method:A total of 80 DFU patients admitted to Shijingshan Teaching Hospital,Capital Medical University from March 2019 to April 2023 were selected as experimental subjects.They were randomly divided into combined group(n=40)and dressing group(n=40)according to computer numbering odd and even method.The dressing group was treated with silver ion hydrogel dressing,and the combined group was treated with NPWT based on the dressing group.The related indicators,ankle�brachial index(ABI),angiogenesis index and nerve conduction velocity before and 28 d after treatment were compared between the two groups.Result:The wound healing time and hospitalization days of the combined group were shorter than those of the dressing group,and the dressing changes was less than that of the dressing group,the differences were statistically significant(P<0.05).After 28 d of treatment,ABI of the two groups increased,and ABI of the combined group was higher than that of the dressing group,the differences were statistically significant(P<0.05).After 28 d of treatment,vascular endothelial growth factor(VEGF)and basic fibroblast growth factor,basic fibroblast growth factor(bFGF)and insulin-like growth factor-1(IGF-1)were higher than those before treatment,endostatin(ES)was lower than that before treatment,VEGF,bFGF and IGF-1 in combined group were higher than those in dressing group,ES was lower than that in dressing group,the differences were statistically significant(P<0.05).After 28 d of treatment,sensory nerve conduction velocity(SCV)and motor nerve conduction velocity(MCV)of common peroneal nerve and median nerve increased in both groups,SCV and MCV of common peroneal nerve and median nerve in combined group were higher than those in dressing group,and the differences were statistically significant(P<0.05).Conclusion:NPWT combined with silver ion hydrogel dressing can promote wound
作者
厉胜
晋炳申
LI Sheng;JIN Bingshen(Shijingshan Teaching Hospital,Capital Medical University,Beijing 100043,China;不详)
出处
《中外医学研究》
2024年第13期21-24,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
糖尿病足溃疡
负压创面疗法
银离子水凝胶敷料
创面愈合
血管新生
Diabetic foot ulcer
Negative pressure wound therapy
Silver ion hydrogel dressing
Wound healing
Angiogenesis
