摘要
非酒精性脂肪性肝病(NAFLD)在我国的发病率逐年上升。肠道屏障是肠道能防止肠腔内的有害物质如细菌和内毒素等穿过肠黏膜进入体内其他组织器官和血液循环的结构和功能的总和,通常将肠道屏障分为肠道机械屏障、肠道免疫屏障、肠道化学屏障、肠道微生物屏障。本文对肠道黏膜屏障功能在NAFLD发病机制中的重要作用,以及肠道屏障功能的研究进行总结,探讨NAFLD的预防和治疗。
The incidence of nonalcoholic fatty liver disease(NAFLD)in China is increasing year by year.Intestinal barrier refers to the sum of the structure and function of the intestine to prevent harmful substances such as bacteria and endotoxin in the intestinal cavity from passing through the intestinal mucosa into other tissues and organs in the body and blood circulation.Intestinal barrier is usually divided into intestinal mechanical barrier,intestinal immune barrier,intestinal chemical barrier and intestinal microbial barrier.This article summarizes the important role of intestinal mucosal barrier function in the pathogenesis of NAFLD and the study of intestinal barrier function,and discusses the prevention and treatment of NAFLD.
作者
高书娟
戴光荣
GAO Shu-juan;DAI Guang-rong(Department of Digestive Medicine,Affiliated Hospital of Yan'an University,Yan'an 716000,Shaanxi,China)
出处
《医学信息》
2024年第10期175-178,共4页
Journal of Medical Information
基金
延安大学附属医院科学技术研究发展计划(编号:2022ZD-07)。
关键词
非酒精性脂肪性肝病
肠道屏障
黏膜屏障
Non-alcoholic fatty liver disease
Intestinal barrier
Mucosal barrier
