摘要
地图样萎缩是年龄相关性黄斑变性(ARMD)的一种中期及进展期表现。由于地图样萎缩发病机制复杂,目前尚无强有效的治疗方法,患者最终将丧失中心视力。研究显示,补体系统的过度激活与地图样萎缩的发生及进展密切相关。文章就地图样萎缩的临床表现、发病机制、补体系统在发病进程中的作用及治疗进展等进行综述。
Geographic atrophy(GA)is an intermediate and advanced stage of age-related macular degeneration(ARMD).Due to the complex pathogenesis of GA,there are no effective treatments at present,and eventually patients will lose central vision.Studies have shown that excessive activation of the complement system is closely related to the occurrence and progression of GA.This review will offer a summary of the clinical features,pathogenesis,the role of complement system in the pathology and the treatment progress of GA.
作者
王博昭
张鹏
Wang Bozhao;Zhang Peng(Xi an No.3 Hospital,the Affiliated Hospital of Northwest University,Xi an 710018,Shaanxi Province,China)
出处
《国际眼科杂志》
CAS
2024年第6期899-901,共3页
International Eye Science
关键词
年龄相关性黄斑变性
地图样萎缩
补体系统
治疗
进展
age-related macular degeneration
geographic atrophy
complement system
treatment
progress
