摘要
目的 观察有无短暂性视网膜缺血发作(RTIA)史的非动脉炎性视网膜中央动脉阻塞(NA-CRAO)患者中心视力变化,探讨RTIA对患眼中心视力的保护作用。方法 2016年1月—2023年6月河南省人民医院诊治NA-CRAO患者175例(175眼),无RTIA史95例为无RTIA组,RTIA至NA-CRAO发病间隔时间≤2周38例为近期RTIA组,RTIA至NA-CRAO发病间隔时间>2周42例为远期RTIA组。比较3组性别、年龄、合并症(高血压、糖尿病、高胆固醇血症、冠状动脉疾病)、吸烟史、饮酒史、脑梗死病史、发病至就诊时间、住院时间。3组入院时行光学相干断层扫描,测量患眼及健眼黄斑中心凹视网膜厚度(CRT)。3组均采用保守治疗,分别于入院时及治疗1、3个月检测患眼最佳矫正视力(BCVA),并将BCVA换算为最小分辨角对数(logMAR)视力,比较中心视力好转率。结果 (1)3组年龄,发病至就诊时间,住院时间,男性、吸烟、饮酒、有脑梗死史及合并高血压、糖尿病、高胆固醇血症、冠状动脉疾病比率比较差异均无统计学意义(P>0.05)。(2)3组入院时患眼CRT比较差异有统计学意义(F=17.771,P<0.001),健眼CRT比较差异无统计学意义(F=2.084,P=0.128)。近期RTIA组入院时患眼CRT[(308.39±34.46)μm]小于远期RTIA组[(341.00±44.38)μm]和无RTIA组[(360.74±50.40)μm](P<0.05),远期RTIA组与无RTIA组比较差异无统计学意义(P>0.05)。(3)3组入院及治疗1、3个月时BCVA(logMAR)比较差异均有统计学意义(F=3.107,P=0.047;F=3.668,P=0.028;F=4.737,P=0.010),治疗1、3个月时BCVA(logMAR)与入院时比较差异均无统计学意义(P>0.05)。入院及治疗1、3个月时近期RTIA组BCVA(logMAR)(2.10±0.88、2.00±0.88、1.90±0.86)均好于远期RTIA组(2.46±0.81、2.37±0.80、2.31±0.78)和无RTIA组(2.47±0.77、2.40±0.76、2.35±0.75)(P<0.05),远期RTIA组与无RTIA组比较差异无统计学意义(P>0.05)。(4)治疗1、3个月时近期RTIA组(18.4%、26.3%)、远期RTIA组(14.3%、23.8%)、无RTIA组(13.7%�
Objective To observe the changes in central visual acuity in patients with non-arteritic central retinal artery occlusion(NA-CRAO)with or without a history of retinal transient ischemic attack(RTIA),and to explore the role of RTIA in protecting central visual acuity.Methods Totally 175patients(175eyes)with NA-CRAO in Henan Provincial People’s Hospital from January 2016to June 2023 were divided into 95patients(95eyes)without RTIA history(non-RTIA group),38patients(38eyes)with≤2weeks from RTIA onset to NA-CRAO onset(short-term RTIA group)and 42patients(42eyes)with>2weeks from RTIA onset to NA-CRAO onset(long-term RTIA group).The gender,age,comorbidities(hypertension,diabetes,hypercholesterolemia,coronary artery disease),smoking habits,alcohol consumption history,history of cerebral infarction,time from onset to visit,and length of hospital stay were compared among three groups.All patients underwent optical coherence tomography on admission to measure the central retinal thickness(CRT)of both affected and healthy eyes.All three groups received conservative treatment.The best-corrected visual acuity(BCVA)of the affected eyes was tested on admission and after 1-and 3-month treatment.The BCVA was converted to logMAR visual acuity,and the improvement rate of central visual acuity was compared.Results(1)There were no significant differences in the age,time from onset to visit,length of hospital stay,male ratio,and percentages of patients with smoking habits,alcohol consumption history,history of cerebral infarction,and comorbidities as hypertension,diabetes,hypercholesterolemia and coronary artery disease among three groups(P>0.05).(2)There was a significant difference in the CRT of the affected eyes among three groups(F=17.771,P<0.001),while there was no significant difference in the CRT of the healthy eyes(F=2.084,P=0.128).The CRT on admission was thinner in short-term RTIA group[(308.39±34.46)μm]than that in long-term RTIA group[(341.00±44.38)μm]and non-RTIA group[(360.74±50.40)μm](P<0.05),and showed no sig
作者
刘东波
张炳贤
赵琼蕊
张杰文
赵建华
李富贵
LIU Dongbo;ZHANG Bingxian;ZHAO Qiongrui;ZHANG Jiewen;ZHAO Jianhua;LI Fugui(Department of Neurology,Henan Provincial People’s Hospital,Zhengzhou University People’s Hospital,Zhengzhou,Henan 450003,China;Clinical Scientific Service Center,Henan Provincial People’s Hospital,Zhengzhou University People’s Hospital,Zhengzhou,Henan 450003,China;Ophthalmology Medical Technology Examination Room,Henan Provincial People’s Hospital,Henan Eye Hospital,Zhengzhou,Henan 450003,China)
出处
《中华实用诊断与治疗杂志》
2024年第3期259-262,共4页
Journal of Chinese Practical Diagnosis and Therapy
基金
河南省医学科技攻关省部共建重点项目(SBGJ202102034)。
