摘要
目的 利用目前常用的评判肥胖的指标体重指数(BMI)与孟德尔随机化(MR)方法来分析肥胖与视网膜中央动脉阻塞(CRAO)之间的因果关系。方法 采用全基因组关联研究的汇总统计数据,进行双样本MR分析。将暴露的遗传工具分为男性组(n=60 586,SNP=2 736 876,欧洲男性)及女性组(n=171 977,SNP=2 494 613,欧洲女性);CRAO作为结局。BMI的工具变量来自综合流行病学单位公共可用数据;结局数据CRAO来自FinnGen数据库。采用逆方差加权(IVW)、加权中位数分析BMI与CRAO之间的潜在因果关系。结果 IVW分析结果显示,BMI水平升高显著增加了男性发生CRAO的风险(OR=4.57,95%CI为1.32~15.82,P=0.016)以及女性发生CRAO的风险(OR=3.48,95%CI为1.40~8.63,P=0.007)。同时,加权中位数和MR-Egger分析的结果支持上述结论。除此之外,本研究结果并不存在异质性及多效性。结论 BMI升高与CRAO发生呈正相关。这一研究为BMI水平升高的无症状者提供了有效的CRAO预防策略。
Objective To analyze the causal relationship between obesity and central retinal artery occlusion(CRAO)based on body mass index(BMI),which is commonly used to measure obesity,and Mendelian randomization(MR)method.Methods Two-sample MR analysis was performed using summary statistics from genome-wide association studies.Exposed genetic tools were divided into the men group(n=60586,SNP=2736876,European men)and women group(n=171977,SNP=2494613,European women);CRAO was selected as the outcome.The instrumental variable for BMI came from the Integrative Epidemiology Unit(IEU)publicly available data;the outcome CRAO data came from the FinnGen database.Inverse variance weighting(IVW)and weighted median(WM)were used to analyze the potential relationship between BMI and CRAO.Results IVW showed that the increased BMI level significantly increased the risk of CRAO in men[OR=4.57,95%CI:1.32-15.82,P=0.016]and the risk of CRAO in women[OR=3.48,95%CI:1.40-8.63,P=0.007].Meanwhile,the WM and MR-Egger analysis results supported the above conclusions.In addition,there was no heterogeneity or pleiotropy in the results of this study.Conclusion The increase in BMI is positively correlated with the occurrence of CRAO.This study provides an effective CRAO prevention strategy for asymptomatic patients with elevated BMI levels.
作者
刘钊
周丽
谢仟
蔡善君
LIU Zhao;ZHOU Li;XIE Qian;CAI Shanjun(Department of Ophthalmology,Affiliated Hospital of Zunyi Medical University,Guizhou Ophthalmology Hospital,Guizhou Branch of National Ophthalmology Clinical Research Center,Special Key Laboratory of Ocular Diseases of Guizhou Province,Zuiyi 563003,Guizhou Province,China;Department of Clinical Medicine,the First Clinical College of Zunyi Medical University,Zuiyi 563003,Guizhou Province,China)
出处
《眼科新进展》
CAS
北大核心
2024年第3期193-196,共4页
Recent Advances in Ophthalmology
基金
国家自然科学基金面上项目(编号:31871261)。
关键词
体重指数
视网膜中央动脉阻塞
孟德尔随机化
body mass index
central retinal artery occlusion
Mendelian randomization
