摘要
目的:观察地屈孕酮联合戊酸雌二醇治疗围绝经期功能失调性子宫出血(DUB)患者的效果。方法:回顾性分析2021年3月至2023年1月该院收治的80例围绝经期DUB患者的临床资料,根据治疗方案不同将其分为对照组和研究组各40例。对照组采用戊酸雌二醇片治疗,研究组在对照组基础上联合地屈孕酮片治疗。比较两组临床疗效,治疗前后子宫内膜厚度,止血效果,治疗前后血红蛋白(Hb)、性激素[孕激素(P)、雌二醇(E_(2))、黄体生成素(LH)、卵泡刺激素(FSH)]水平,以及不良反应发生率。结果:研究组治疗总有效率为92.50%(37/40),高于对照组的75.00%(30/40),差异有统计学意义(P<0.05);治疗后,两组子宫内膜厚度均小于治疗前,且研究组小于对照组,差异有统计学意义(P<0.05);治疗后,两组Hb水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);研究组出血控制时间、完全止血时间均短于对照组,差异有统计学意义(P<0.05);两组E_(2)、FSH、LH、P水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:地屈孕酮联合戊酸雌二醇治疗围绝经期DUB患者可提高治疗总有效率和Hb水平,缩短出血控制时间、完全止血时间,减小子宫内膜厚度,降低性激素水平,其效果优于单纯戊酸雌二醇治疗。
Objective:To observe effects of Dydrogesterone combined with Estradiol valerate in treatment of patients with perimenopausal dysfunctional uterine bleeding(DUB).Methods:The clinical data of 80 patients with perimenopausal DUB admitted to this hospital from March 2021 to January 2023 were retrospectively analyzed.According to different treatment options,they were divided into control group and study group,40 cases in each group.The control group was treated with Estradiol valerate tablets,while the study group was treated with Dydrogesterone tablets on the basis of that of the control group.The clinical efficacy,the endometrial thickness before and after the treatment,the hemostatic effect,the levels of hemoglobin(Hb)and sex hormones[progesterone(P),estradiol(E_(2)),luteinizing hormone(LH),follicle stimulating hormone(FSH)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 92.50%(37/40),which was higher than 75.00%(30/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the endometrial thickness levels of the two groups were smaller than those before the treatment,that of the study group was smaller than that of the control group,and the differences were statistically significant(P<0.05).After the treatment,the Hb levels of the two groups were higher than those before the treatment,that of the study group was higher than that of the control group,and the differences were statistically significant(P<0.05).The bleeding control time and the complete hemostasis time of the study group were shorter than those of the control group,and the differences were statistically significant(P<0.05).The levels of E_(2),FSH,LH and P in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the inciden
作者
占娟
李勇
ZHAN Juan;LI Yong(Department of Obstetrics and Gynecology of Luoshan County People’s Hospital,Xinyang 464200 Henan,China)
出处
《中国民康医学》
2024年第9期85-87,91,共4页
Medical Journal of Chinese People’s Health
关键词
地屈孕酮
戊酸雌二醇
围绝经期
功能失调性子宫出血
性激素
止血
子宫内膜厚度
Dydrogesterone
Estradiol valerate
Perimenopausal period
Dysfunctional uterine bleeding
Sex hormone
Hemostasis
Endometrial thickness
