摘要
目的 观察蒲地蓝消炎口服液联合降阶梯方案治疗儿童疱疹性咽峡炎(HA)的临床效果。方法选取2021年6月至2023年6月商河县人民医院收治的80例HA患儿为研究对象,按照随机数字表法分为对照组(n=40)与研究组(n=40)。对照组给予常规对症治疗,研究组给予蒲地蓝消炎口服液联合降阶梯方案治疗,比较两组临床疗效、中医证候积分、炎症因子水平及不良反应总发生率。结果 研究组治疗总有效率为95.00%(38/40),高于对照组的77.50%(31/40)(P <0.05);治疗后,两组中医证候积分均降低,且研究组中医证候积分低于对照组(P <0.05);治疗后,两组白细胞介素(IL)-2水平均升高,IL-6、IL-10水平均降低,且研究组IL-2水平高于对照组,IL-6、IL-10水平低于对照组(P <0.05);研究组不良反应总发生率为2.50%(1/40),低于对照组的20.00%(8/40)(P<0.05)。结论 蒲地蓝消炎口服液联合降阶梯方案治疗儿童HA的临床效果显著,能够改善中医证候、炎症因子水平,降低不良反应的发生风险,值得推广。
Objective To observe the clinical effect of Pudilan Anti-inflammatory Oral Liquid combined with de-escalation regimen in the treatment of children with herpetic angina(HA).Methods A total of 80 children with HA in Shanghe People’s Hospital from June 2021 to June 2023 were selected and divided into control group(n=40)and study group(n=40)according to the random number table method.The control group was given conventional symptomatic treatment,and the study group was given Pudilan Anti-inflammatory Oral Liquid combined with de-escalation regimen treatment.The clinical efficacy,traditional Chinese medicine(TCM)syndrome score,inflammatory factor levels,and total incidence of adverse reactions were compared between the two groups.Results The total effective rate in the study group was 95.00%(38/40),which was higher than 77.50%(31/40)in the control group(P<0.05).After treatment,the TCM syndrome score in both groups were decreased,and the TCM syndrome score in the study group was lower than that in the control group(P<0.05).After treatment,the interleukin(IL)-2 level in both groups was increased,the IL-6 and IL-10 levels in both groups were decreased,and the IL-2 level in the study group was higher than that in the control group,the IL-6 and IL-10 levels in the study group were lower than those in the control group(P<0.05).The total incidence of adverse reactions in the study group was 2.50%(1/40),which was lower than 20.00%(8/40)in the control group(P<0.05).Conclusion Pudilan Anti-inflammatory Oral Liquid combined with de-escalation regimen in the treatment of children with HA has significant clinical effect,which can improve the TCM syndrome and the level of inflammatory factors,reduce the risk of adverse reactions,and is worth promoting.
作者
崔学英
宋云红
CUI Xueying;SONG Yunhong(Department of Otolaryngology,Shanghe People’s Hospital,Shandong Province,Shanghe 251600,China)
出处
《妇儿健康导刊》
2024年第9期58-62,共5页
JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE
关键词
蒲地蓝消炎口服液
降阶梯方案
儿童疱疹性咽峡炎
Pudilan Anti-inflammatory Oral Liquid
De-escalation regimen
Children with herpetic angina
