摘要
目的了解新疆生产建设兵团肺结核(pulmonary tuberculosis,PTB)患者治疗转归情况以及探究影响其转归的危险因素,为兵团地区肺结核防治提供科学依据。方法选取兵团2016—2022年期间登记的结核病患者,采用回顾性分析流行病学方法对研究对象进行了基本人口学资料及临床资料的整理。采用log-rank检验进行单因素分析以及Cox多因素回归模型分析肺结核患者治疗转归的影响因素。结果2016—2022年在新疆生产建设兵团结核病管理信息系统中共登记8838例结核病患者,其中495例未治疗,43例诊断变更,301例无治疗结果,6例诊断为肺外结核,11例诊断为气管支气管结核,最终纳入研究7982例肺结核患者。7982例肺结核患者中7578例(94.94%)治疗成功,404例(5.06%)发生不良结局(包括32例失败、13例结核死亡、173例非结核死亡、12例丢失、94例不良反应、10例转入耐多药治疗、70例其他)。多因素Cox回归分析结果显示,>30~60岁与>60岁年龄组(OR=1.565,P=0.009;OR=2.960,P<0.001)、少数民族(OR=1.526,P<0.001)、糖尿病患者(OR=1.696,P=0.002)、现地址类型为本省其他地区及外省患者(OR=1.419,P=0.004;OR=1.624,P=0.001)、复治患者(OR=1.910,P<0.001)、没有接受基层管理(OR=1.351,P=0.003)是兵团肺结核患者治疗不成功的危险因素。结论兵团地区肺结核患者的治疗成功率较高,但仍应加强对高龄、少数民族、糖尿病患者,非本地的流动人口、复治患者以及没有接受基层管理患者的治疗管理。
Objective To investigate the treatment outcomes of patients with pulmonary tuberculosis(PTB)in Xinjiang Production and Construction Corps and to explore the risk factors affecting these outcomes,so as to provide a scientific basis for the prevention and treatment of pulmonary tuberculosis in the corps region.Methods TB patients registered in the Corps from 2016 to 2022 were selected,and the basic demographic and clinical data of the research objects were collected by retrospective method.Log-rank test was used for univariate analysis and the Cox multivariate regression model was used to analyze the influencing factors of treatment outcomes of patients with pulmonary tuberculosis.Results From 2016 to 2022,a total of 8838 TB patients were registered in the TB Management Information System of Xinjiang Production and Construction Corps,of which 495 cases were untreated,43 cases had changed diagnoses,301 cases had no treatment outcomes,6 cases were diagnosed as extrapulmonary tuberculosis,11 cases were diagnosed as tracheobronchial tuberculosis,and finally 7982 TB patients were included in the study.Of the 7982 patients,7578(94.94%)were treated successfully,while 404(5.06%)had adverse outcomes(including 32 cases of failure,13 cases of TB death,173 cases of non-TB death,12 cases lost to follow-up,94 cases of adverse reactions,10 cases transferred to multi-drug resistance treatment,and 70 other cases).Multivariate Cox regression analysis showed that the>30 to 60-year-old and>60-year-old age groups(OR=1.565,P=0.009;OR=2.960,P<0.001),belonging to ethnic minorities(OR=1.526,P<0.001),being a patients with diabetes mellitus(OR=1.696,P=0.002),current address being in other areas of the province or patients from other provinces(OR=1.419,P=0.004;OR=1.624,P=0.001),receiving retreatment(OR=1.910,P<0.001),and absence of primary care management(OR=1.351,P=0.003)were the risk factors for unsuccessful treatment outcomes in the corps'pulmonary tuberculosis patients.Conclusions The treatment success rate of pulmonary tuberculosis patie
作者
杨柳根
马晓玲
范奔
赵永年
董改梅
段丽丽
德丽娜·赛日克
李凡卡
YANG Liugen;MA Xiaoling;FAN Ben;ZHAO Yongnian;DONG Gaimei;DUAN Lili;Delina Sairike;LI Fanka(Department of Preventive Medicine,Medical School,Shihezi University,Shihezi,Xinjiang 832000,China;Xinjiang Production and Construction Corps Center for Disease Control and Prevention,Urumqi,Xinjiang 830002,China)
出处
《中国热带医学》
CAS
北大核心
2024年第4期456-462,共7页
China Tropical Medicine
基金
新疆生产建设兵团疾病预防控制中心自主课题项目(No.BTCDCKY202202)。
关键词
肺结核
治疗转归
影响因素
新疆生产建设兵团
Tuberculosis,pulmonary
treatment outcome
influencing factors
Xinjiang Production and Construction Corps
