摘要
类风湿关节炎(RA)是一种常见的自身免疫性疾病,可导致全身炎症和侵蚀性关节破坏。RA患者的症状可能导致严重残疾,生活质量显著降低。据统计,美国女性患RA的总体风险为3.6%,美国男性为1.7%,全球患病率估计为0.46%。虽然RA的发病机制复杂,涉及许多因素的相互作用,但调节性T细胞(Treg)在疾病发展和进展中的作用越来越受到关注。作为辅助性T细胞的一个特殊亚群,Treg在维持体内平衡和自我耐受方面起着重要作用,防止自身免疫性疾病的发展。RA患者的Treg细胞以功能受损和表型改变为特征。它们显示出对Th17细胞的可塑性增加,抑制能力降低。除了Treg细胞的抑制功能外,它们的有效性还取决于它们迁移到炎症组织中的能力。随着越来越多的关于Treg细胞在自身免疫疾病方面作用机制理解的增加,靶向Treg治疗自身免疫疾病显示出良好的前景。
Rheumatoid arthritis(RA)is a common autoimmune disease that can lead to systemic inflammation and erosive joint damage.The symptoms of RA patients may lead to severe disability and a significant decrease in quality of life.According to statistics,the overall risk of RA for women in the United States is 3.6%,for men in the United States it is 1.7%,and the global prevalence is estimated to be 0.46%.Although the pathogenesis of RA is complex and involves the interaction of many factors,the role of regulatory T cells(Tregs)in disease development and progression is receiving increasing attention.As a special subgroup of helper T cells,Treg plays an important role in main⁃taining balance and self tolerance in the body,preventing the development of autoimmune diseases.Treg cells in RA patients are character⁃ized by impaired function and phenotypic changes.They exhibit increased plasticity and decreased inhibitory ability on Th17 cells.In addi⁃tion to the inhibitory function of Treg cells,their effectiveness also depends on their ability to migrate to inflammatory tissues.With the increasing understanding of the mechanism of Treg cells in autoimmune diseases,targeting Treg for the treatment of autoimmune diseases has shown promising prospects.
作者
陈海龙
单林燕
王子涵
Hailong Chen;Linyan Shan;Zihan Wang(Dingxi Campus of Gansu University of Traditional Chinese Medicine,Dingxi,Gansu 743099)
