摘要
目的将子宫动脉栓塞(UAE)术与依沙吖啶羊膜腔注药联合用于妊娠中期需终止妊娠的胎盘植入(PA)患者中,观察其应用效果,为PA患者治疗方案的合理选择提供参考。方法本研究为回顾性分析,收集2020年1月~2021年8月于濮阳市妇幼保健院终止妊娠的95例妊娠中期PA患者临床资料,根据引产方式不同分为对照组(47例,依沙吖啶羊膜腔注药引产)及观察组(48例,UAE术联合依沙吖啶羊膜腔注药引产),比较两组临床疗效、引产前后血清血管内皮生长因子(VEGF)、可溶性酪氨酸激酶受体-1(SFlt-1)、性激素水平,记录两组并发症情况。结果与对照组相比,观察组阴道流血量较少,胎盘组织排出、β-人绒毛膜促性腺激素(HCG)转阴、B超血流消失、住院及月经复常时间较短(P<0.05);两组引产后1d的血清VEGF、SFlt-1、孕酮(P)、泌乳素(PRL)、雌二醇(E2)水平均降低,且观察组更低(P<0.05);与对照组相比,观察组大出血、子宫切除发生率较低(P<0.05)。结论妊娠中期PA患者联合应用依沙吖啶羊膜腔注药与UAE术引产安全有效,能使患者出血量明显减少,并能改善VEGF、SFlt-1、性激素水平,促进身体恢复。
Objective To observe application effect of the combination of uterine artery embolization(UAEAE)and ethacridine amniotic cavity injection used in patients with mid pregnancy placental implantation(PA)who need to terminate pregnancy,and provide reference for the rational selection of treatment plans for PA patients.Method This study was a retrospective analysis,collecting clinical data of 95 mid pregnancy PA patients who terminated their pregnancies at Puyang Maternity and Child Care Centers from January 2020 to August 2021 According to the different methods of induced labor,they were divided into a control group(47 cases,induced labor with ethacridine amniotic cavity injection)and an observation group(48 cases,induced labor with UAE surgery combined with ethacridine amniotic cavity injection).The clinical efficacy,serum vascular endothelial growth factor(VEGEG F),soluble tyrosine kinase receptor-1(SFlt-1)and sex hormone levels before and after induction of labor were compared between the two groups,and the complications of the two groups were recorded.Results Compared with the control group,the observation group had less vaginal bleeding,shorter placental tissue discharge,negative conversion ofβ-human chorionic gonadotropin(HCG),disappearance of B-ultrasound blood flow,shorter hospitalization and menstrual recovery time(P<0.05).The levels of serum VEGEG F,SFlt-1,progesterone(P),prolactin(PRL)and estradiol(E2)in the two groups decreased at 1 day after induction of labor,and those in the observation group were lower(P<0.05).Compared with the control group,the observation group had a lower incidence of major bleeding and hysterectomy(P<0.05).Conclusion The use of UAE combined with ethacridine amniotic injection for induction of labor in mid pregnancy PA patients who need to terminate pregnancy is safe and effective,which can significantly reduce bleeding and improve levels of VEGEG F,SFlt-1,and sex hormones,promoting physical recovery.
作者
杨瑞琴
黄亚南
YANG Rui-qin;HUANG Ya-nan(Department of Obstetrics and Gynecology,Puyang Maternity and Child Care Centers,Puyang 457000,Henan Province,China)
出处
《罕少疾病杂志》
2024年第5期115-117,共3页
Journal of Rare and Uncommon Diseases
关键词
胎盘植入
妊娠中期
终止妊娠
依沙吖啶
子宫动脉栓塞术
性激素
Placenta Accreta
Mid Pregnancy
Terminate Pregnancy
Ethacridine
Uterine Artery Embolization
Sex Hormone
