摘要
基于隐结构模型和关联规则分析扩张型心肌病心力衰竭的方药规律,为临床辨证论治扩张型心肌病心力衰竭及指南的制定提供理论支撑。系统检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed),筛选方药治疗扩张型心肌病心力衰竭的相关文献并提取资料。运用Microsoft Excel 2019建立数据库,通过Lantern 5.0及Rstudio软件对频率>4.00%的中药进行隐结构模型与关联规则分析,结合频数结构模型,总结扩张型心肌病心力衰竭的方药规律。最终纳入中医处方175首,涉及单味中药128味,累计使用频次1847次,高频中药包括黄芪、丹参、茯苓、桂枝、甘草等,功效以补虚药、活血化瘀药和解表药为主。隐结构模型分析共获得17个隐变量、34个隐类、6个综合聚类模型,15个核心方剂,以方测证推断扩张型心肌病心力衰竭证型以心气阳虚证、气虚血瘀证、心肾阳虚证和气阴两虚证为主。关联规则分析获得54条强关联规则,支持度最高的是丹参-黄芪,置信度最高的是丹参-桂枝-麦冬-黄芪。扩张型心肌病心力衰竭为本虚标实之证,核心病机为“虚”“瘀”“水”,与心、肺、脾关系密切,治法以益气温阳为主,随证结合活血化瘀,行气利水治法。
The latent structure model and association rules analysis were employed to explore the compatibility rules of prescriptions for heart failure of dilated cardiomyopathy,with a view to providing theoretical support for the clinical treatment of this disease based on syndrome differentiation and the formulation of guidelines.The articles about the treatment of heart failure of dilated cardiomyopathy were retrieved from CNKI,Wanfang,VIP,and SinoMed.The database was established in Microsoft Excel 2019.Lantern 5.0 and Rstudio were used to analyze the latent structure and association rules of Chinese medicine with the frequency greater than 4.00%.Furthermore,the frequency structure model was used to mine the rules of prescriptions for heart failure of dilated cardiomyopathy.The study included 175 traditional Chinese medicine(TCM)prescriptions,involving 128 Chinese medicines,with the cumulative frequency of 1847.High-frequency medicines included Astragali Radix,Salviae Miltiorrhizae Radix et Rhizoma,Poria,Cinnamomi Ramulus,Glycyrrhizae Radix et Rhizoma,with the main effects of tonifying,activating blood,resolving stasis,and releasing exterior.A total of 17 hidden variables,34 hidden categories,and 6 comprehensive cluster models,along with 15 core prescriptions,were obtained.According to the prescriptions,the patients mainly had the syndromes of heart-Yang and Qi deficiency,Qi deficiency and blood stasis,heart-kidney Yang deficiency or Qi-Yin deficiency.Fifty-four strong association rules were obtained through association rule analysis.The highest degree of support was observed for the combination of Salviae Miltiorrhizae Radix et Rhizoma-Astragali Radix,while the highest degree of confidence was found for the combination of Salviae Miltiorrhizae Radix et Rhizoma-Cinnamomi Ramulus-Ophiopogonis Radix-Astragali Radix.The heart failure of dilated cardiomyopathy,characterized by internal deficiency and excess manifestations,is attributed to deficiency,stasis,and water.These factors are closely associated with the heart,lung,a
作者
吴文俊
张赤道
卫靖靖
郭红鑫
郝鹏乐
李雪
朱明军
WU Wen-jun;ZHANG Chi-dao;WEI Jing-jing;GUO Hong-xin;HAO Peng-le;LI Xue;ZHU Ming-jun(Department of Cardiovascular Diseases,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2024年第7期1956-1965,共10页
China Journal of Chinese Materia Medica
基金
国家自然科学基金重点项目(82030120)
国家中医药管理局中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者项目(国中医药人教函[2021]203号)。
关键词
扩张型心肌病心力衰竭
隐结构
关联规则
用药规律
heart failure of dilated cardiomyopathy
latent structure
association rule
medication rule
