摘要
目的:研究海州常山Clerodendrum trichotomum Thunb.茎的化学成分。方法:综合运用硅胶、凝胶、ODS等柱色谱技术进行分离纯化,结合MS、^(1)H-NMR、^(13)C-NMR等波谱技术鉴定化合物的结构。结果:从海州常山茎中分离得到14个化合物,分别鉴定为:弥罗松酚(1)、villoson A(2)、粘霉烯醇(3)、3-O-乙酰齐墩果醛(4)、teuvincenone E(5)、异地黄苷(6)、deacylisomartynoside(7)、毛蕊花糖苷(8)、异毛蕊花糖苷(9)、去咖啡酰基毛蕊花糖苷(10)、(+)-南烛木树脂酚-3α-O-β-D-葡萄糖苷(11)、(-)-南烛木树脂酚-3α-O-β-D-葡萄糖苷(12)、南烛木树脂酚(13)、3,12-O-β-D-二吡喃葡萄糖基-11,16-二羟基松香醇-8,11,13-三烯(14)。结论:其中,化合物11~13为首次从该属植物中分离得到,化合物1、7、14为首次从该植物中分离得到。
Objective:To study the chemical constituents from the stems of Clerodendrum trichotomum.Methods:The compounds were isolated and purified by column chromatographic methods,including silica gel,Sephadex LH-20,ODS and so on.The structures of compounds were identified by MS,^(1)H-NMR,^(13)C-NMR and other spectral techniques.Results:Fourteen compounds were isolated from the stems of Clerodendrum trichotomum and identified as ferruginol(1),villoson A(2),glutinol(3),3-O-acetyl oleanolic aldehyde(4),teuvincenone E(5),isomartynoside(6),deacylisomartynoside(7),verbascoside(8),isoverbascoside(9),decaffeoylverbascoside(10),(+)-lyoniresinol-3α-O-β-D-glucoside(11),(-)-lyoniresinol-3α-O-β-D-glucoside(12),lyoniresinol(13),3,12-O-β-D-diglucopyranosyl-11,16-dihydroxyabieta-8,11,13-triene(14),respectively.Conclusion:Among them,compounds 11 to 13 are isolated from Clerodendrum genus for the first time,compounds 1,7,14 are isolated from Clerodendrum trichotomum for the first time.
作者
张宇
岑银芝
陈亮
李勇军
孙建博
李林珍
ZHANG Yu;CEN Yin-zhi;CHEN Liang;LI Yong-jun;SUN Jian-bo;LI Lin-zhen(College of Pharmacy,Guizhou Medical University,Guiyang 550025,China;Engineering Research Center for the Development and Application of Ethnic Medicine and TCM(Ministry of Education),Guizhou Medical University,Guiyang 550004,China;State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang 550004,China;Department of Natural Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China)
出处
《中药材》
CAS
北大核心
2022年第4期857-861,共5页
Journal of Chinese Medicinal Materials
基金
国家自然科学基金资助项目(81860689)
贵州省科技合作计划项目(黔科合LH字[2015]7359)
关键词
海州常山
化学成分
苯丙素类
结构鉴定
Clerodendrum trichotomum Thunb.
Chemical constituents
Phenylpropanoids
Structural identification
