摘要
目的:探讨含I型血小板结合蛋白基序的解聚蛋白样金属蛋白酶7(ADAMTS7)rs62011052和rs62012628位点多态性与原发性高血压的相关性。方法:选取原发性高血压病例211例,选取同时期体检血压正常人群208例作为对照组,Sanger法测序测定基因型;SPSS25.0软件对组间临床资料、基因多态性与原发性高血压的相关性进行比较分析。结果:(1)与对照组相比,高血压组BMI、脉压差、收缩压、舒张压、甘油三酯、总胆汁酸、尿酸更高,静息心率更快,高密度脂蛋白更低(P<0.05);其余临床资料差异无统计学意义(P>0.05)。(2)两组之间的rs62011052、rs62012628位点基因型分布均符合Hardy-Weinberg平衡(P>0.05);rs62011052、rs62012628位点基因型频率和等位基因频率在两组间的差异无统计学意义(P>0.05),按照性别对两组进行分层后分析,差异仍然无统计学意义(P>0.05)。(3)调整可能混杂后,不同遗传模型下携带rs62011052、rs62012628位点不同基因型的人群与高血压发病风险未见明显相关性(P>0.05)。(4)rs62011052不同遗传模型下各基因型之间的血压值差异均无统计学意义(P>0.05);rs62012628位点在共显性模型下不同基因型间的舒张压差异具有统计学意义(P<0.05),随后进行两两比较发现,共显性模型中基因型CT的舒张压低于基因型CC(P<0.05),在显性模型下,CT+TT基因型的血压值低于CC基因型(P<0.05),其余不同遗传模型下各基因型之间的血压值差异均无统计学意义(P>0.05)。结论:ADAMTS7基因rs62012628位点T等位基因与较低的血压值水平有关。
Objective:To investigate the association of A disintegrin and metalloproteinase with thrombospondin motifs 7(ADAMTS7)rs62011052 and rs62012628 locus polymorphisms with essential hypertension.Methods:211 cases of essential hypertension were selected,and 208 cases of people with normal blood pressure in the same period of physical examination were selected as the control group,and the genotype was determined by Sanger method sequencing;SPSS25.0 software was used to compare the correlation between clinical data,gene polymorphism and essential hypertension between groups.Results:(1)Compared to the control group,the hypertensive group had higher BMI,pulse pressure difference,systolic blood pressure,diastolic blood pressure,triglycerides,total bile acids,uric acid,faster resting heart rate and lower HDL(P<0.05);the remaining clinical information was not statistically significant(P>0.05).(2)The genotype distribution of the rs62011052 and rs62012628 loci between the two groups was consistent with Hardy-Weinberg equilibrium(P>0.05);the differences in genotype frequency and allele frequency at the rs62011052 and rs62012628 loci between the two groups were not statistically significant(P>0.05),and after stratifying the two groups by sex analysis,the differences remained statistically insignificant(P>0.05).(3)After adjusting for possible confounding,no significant association was seen between people carrying different genotypes at the rs62011052 and rs62012628 loci and the risk of developing hypertension under different genetic models(P>0.05).(4)The difference in blood pressure values between genotypes under the different genetic models was not statistically significant at rs62011052(P>0.05);the difference in diastolic blood pressure between genotypes under the co-dominant model was statistically significant at rs62012628(P<0.05),and a subsequent two-by-two comparison revealed that the diastolic blood pressure of genotype CT was lower than that of genotype CC in the co-dominant model(P<0.05),the CT+TT genotype had lower bloo
作者
陈壁文
黄辉
王忠
CHEN Bi-wen;HUANG Hui;WANG Zhong(Department of Cardiology,the First Affiliated Hospital of Shihezi University,Xinjiang Shihezi,832008;NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases,Xinjiang Shihezi,832000)
出处
《农垦医学》
2024年第1期15-19,32,共6页
Journal of Nongken Medicine
基金
国家自然科学基金(81460075)
新疆生产建设兵团第三师图木舒克市2021年度科技计划项目(KY2021GG01)。
