摘要
目的:分析慢性胃炎患者采用奥美拉唑联合替普瑞酮治疗的效果。方法:选取2022年1—12月临沂市柳青街道社区卫生服务中心收治的98例慢性胃炎患者作为研究对象,根据随机数字表法分为对照组和观察组,各49例。对照组采用奥美拉唑治疗,观察组采用奥美拉唑联合替普瑞酮治疗。比较两组治疗效果、临床症状、胃肠激素水平、不良反应发生情况。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.003)。治疗后,两组腹胀、上腹痛、恶心呕吐、消瘦贫血评分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组胃泌素、胃动素水平高于治疗前,且观察组高于对照组,两组生长抑素水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P=0.013)。结论:奥美拉唑联合替普瑞酮治疗慢性胃炎的效果显著,可缓解患者临床症状,调节胃肠激素水平,且安全性较高。
Objective:To analyze the effect of omeprazole combined with teprenone treatment in patients with chronic gastritis.Methods:A total of 98 patients with chronic gastritis admitted to Linyi City Liuqing Street Community Health Service Center from January 2022 to December 2022 were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 49 cases in each group.The control group was treated with omeprazole,and the observation group was treated with omeprazole combined with teprenone.The therapeutic effect,clinical symptoms,gastrointestinal hormone level,and occurrence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.003).After treatment,the scores of abdominal distention,epigastric pain,nausea and vomiting,emaciation and anemia in the two groups were lower than those before treatment,and the scores in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of gastrin and motilin in the two groups were higher than those before treatment,and the levels in the observation group were higher than those in the control group,while the levels of somatostatin in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.013).Conclusion:Omeprazole combined with teprenone in the treatment of chronic gastritis has significant effects,and can relieve clinical symptoms,and adjust the gastrointestinal hormone levels,with a high safety.
作者
邢振
Xing Zhen(Linyi City Liuqing Street Community Health Service Center,Linyi 276000,Shandong Province,China)
出处
《中国社区医师》
2024年第8期7-9,共3页
Chinese Community Doctors
关键词
慢性胃炎
奥美拉唑
替普瑞酮
胃肠激素
不良反应
Chronic gastritis
Omeprazole
Teprenone
Intestinal hormone
Adverse reactions
