摘要
目的探讨康复干预治疗联合奥美拉唑、替普瑞酮在慢性浅表性胃炎患者中的治疗效果.方法选取2020年1月—2021年9月就诊于我院的128例慢性浅表性胃炎患者,按随机数字表法分为两组,各64例.对照组给予奥美拉唑联合替普瑞酮治疗,观察组在对照组基础上加用康复干预治疗,持续治疗8周.对比两组服药依从性、临床疗效、胃肠激素、炎症反应.结果观察组服药依从性及治疗总有效率均高于对照组,组间差异有统计学意义(P<0.05).治疗前,两组血清胃泌素(GAS)、胃动素(MTL)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平比较,组间差异无统计学意义(P>0.05);治疗后,观察组GAS、MTL水平均高于对照组,IL-6、IL-8、TNF-α水平均低于对照组,组间差异有统计学意义(P<0.05).结论康复干预治疗联合奥美拉唑、替普瑞酮能提高慢性浅表性胃炎患者治疗效果,减轻炎症反应,利于胃肠功能恢复.
Objective To investigate the therapeutic effect of rehabilitation intervention combined with omeprazole and teprenone in patients with chronic superficial gastritis.Methods A total of 128 patients with chronic superficial gastritis who were treated in our hospital from January 2020 to September 2021 were selected and divided into two groups according to the random number table method,with 64 cases in each group.The control group was treated with omeprazole combined with teprenone,and the observation group was additionally treated with rehabilitation intervention on the basis of the control group,with both interventions for 8 weeks.The medication compliance,clinical efficacy,gastrointestinal hormones and inflammatory response were compared between the two groups.Results The medication compliance and the total effective rate of treatment in the observation group were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the levels of serum gastrin(GAS),motilin(MTL),interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)between the two groups(P>0.05);after treatment,the levels of GAS and MTL in the observation group were higher than those in the control group,the levels of IL-6,IL-8,TNF-αwere lower than the control group,the differences between the groups were statistically significant(P<0.05).Conclusion Rehabilitation intervention combined with omeprazole and teprenone can improve the therapeutic effect of patients with chronic superficial gastritis,reduce the inflammatory response,and facilitate the recovery of gastrointestinal function.
作者
刘威威
王震宇
刘洁
LIU Weiwei;WANG Zhenyu;LIU Jie(Department of Gastroenterology,The Third Affiliated Hospital of Sun Yat-Sen University,Yuedong Hospital,Meizhou Guangdong,514700,China)
出处
《反射疗法与康复医学》
2022年第7期37-39,50,共4页
Reflexology And Rehabilitation Medicine
关键词
慢性浅表性胃炎
奥美拉唑
替普瑞酮
康复干预治疗
胃肠激素
炎症反应
Chronic superficial gastritis
Omeprazole
Teprenone
Rehabilitation intervention
Gastrointestinal hormones
Inflammatory response
