摘要
目的 比较直径≤2 cm的单发肝癌患者接受肝切除术和射频消融术后的生存差异。方法 回顾性分析2004—2015年美国SEER数据库中直径≤2 cm的单发肝癌病例,患者均接受了肝切除术或射频消融术治疗,通过倾向性评分匹配筛选病例,分析两组患者的生存情况。结果 经倾向性评分匹配,纳入射频消融组216例,肝切除术组216例,两组临床特征基本一致。生存分析显示射频消融组5年癌症相关生存率为57.2%,明显低于肝切除术组的72.8%,差异有统计学意义(χ~2=7.135,P=0.008);射频消融组5年总生存率为47.6%,明显低于肝切除术组的64.5%,差异有统计学意义(χ~2=8.822,P=0.003)。多因素分析结果显示,射频消融术、单身状态是影响单发肝癌患者相关生存率和总生存率的独立危险因素(P<0.05),年龄是影响总生存率的独立危险因素(P<0.05)。结论 对于直径≤2 cm的单发肝癌患者,相较于射频消融术,肝切除术在癌症相关生存率和总生存率方面更具优势。
Objective To analyzed the long-term outcome of patients with solitary hepatocellular carcinoma (HCC)≤2 cm after liver resection (LR) and radiofrequency ablation (RFA).Method Between 2004 to 2015,patients with solitary small HCC≤2 cm who received LR or RFA were identified from the Surveillance,Epidemiology,and End Results database (SEER).Propensity score matched analysis was used to evaluate the cancer-specific and overall survival rates of the two groups.Result After propensity score matched analysis,the RFA group had 216 cases and LR group had 216 cases.Before treatments,the clinical factors were similar between two groups.The 5-year cancer-specific survival rates (CSS) of RFA and LR were 57.2%and72.8%,respectively (χ~2=7.135,P=0.008).The 5-year overall survival rates (OS) were 47.6%and 64.5%for RFA and LR groups(χ~2=8.822,P=0.003).Multivariate analyses revealed that the RFA treatment and unmarried status were independent prognostic factors of CSS and OS for solitary small HCC patients after LR and RFA.Age<45 years old was associated with longer OS.Conclusion For single small HCC (≤2 cm),LR provided better CSS and OS than RFA.
作者
谭海东
刘立国
韩东冬
刘笑雷
司爽
周瑞泉
杨世伟
杨佩军
刘天同
Tan Haidong;Liu Liguo;Han Dongdong;Liu Xiaolei;Si Shuang;Zhou Ruiquan;Yang Shiwei;Yang Peijun;Liu Tiantong(Second Department of Hepatopancreatobiliary Surgery,China-Japan Friendship Hospital,Beijing 100029,China)
出处
《中国医刊》
CAS
2024年第5期529-533,共5页
Chinese Journal of Medicine
关键词
肝癌
单发
预后
肝切除术
射频消融术
Hepatocellular carcinoma
Solitary
Prognosis
Liver Resection
Radiofrequency ablation
