摘要
目的运用文献计量学方法分析中医药干预脊髓损伤研究发展历程、热点及趋势。方法检索中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、Web of Science核心集1982-2022年收录的中医药干预脊髓损伤研究文献。采用Excel2020绘制发文趋势图,采用VOSviewer1.6.18软件绘制核心作者、关键词共现网络,采用CiteSpace6.1.R3软件绘制关键词聚类、突现知识图谱。结果共纳入文献3068篇,其中中文文献2860篇、英文文献208篇,该研究领域发文量呈波动上升趋势。334位中文核心作者和44位英文核心作者形成多个研究团队,团队间合作较缺乏。除“脊髓损伤”外,中文高频关键词有“电针”“大鼠”“针灸”“神经源性膀胱”“细胞凋亡”等;英文高频关键词有“electroacupuncture”“acupuncture”“expression”“functional recovery”“neural regeneration”等。关键词聚类分析显示,该领域研究主要集中于不同中医药疗法治疗脊髓损伤的临床观察和作用机制方面。关键词突现分析表明,康复治疗、氧化应激反应、炎症反应、炎症因子、自噬、温针灸、八髎穴、夹脊穴、小胶质细胞、动物模型、功能恢复、基因表达等是该领域研究前沿。结论中医药疗法干预脊髓损伤的相关分子机制是当前研究热点;进一步阐明中医药疗法治疗脊髓损伤的作用靶点,同时开展循证级别更高的临床研究以评价疗效是该领域研究趋势。
Objective To analyze the development history,research hotspots and trends of TCM intervention in spinal cord injury using bibliometric methods.Methods Research literature about TCM intervention in spinal cord injury was retrieved from CNKI,VIP,Wanfang Data,and Web of Science from 1982 to 2022.Excel 2020 was used to plot the trend of issuance.VOSviewer 1.6.18 software was used to draw the core authors and keywords co-occurrence network,and CiteSpace 6.1.R3 software was used to draw the keywords clustering and keyword emergence knowledge map.Results A total of 3068 articles were included,including 2860 Chinese articles and 208 English articles,with a fluctuating upward trend in the number of articles published in this research field.334 Chinese core authors and 44 English core authors formed multiple research teams,with a lack of cooperation among the teams.In addition to“spinal cord injury”,Chinese high-frequency keywords included“electroacupuncture”,“rat”,“acupuncture and moxibustion”,“neurogenic bladder”,“apoptosis”,etc.High frequency keywords in English included“electroacupuncture”,“acupuncture”,“expression”,“functional recovery”and“neural regeneration”,etc.Keyword clustering analysis showed that the research in this field mainly focused on the clinical observation and mechanism study of different TCM therapies for spinal cord injury.Keyword emergent analysis showed that rehabilitation,oxidative stress response,inflammatory response,inflammatory factors,autophagy,warm acupuncture,Baliao acupoint,Jiaji acupoint,microglia cells,animal models,functional recovery,gene expression and so on were the research frontiers in this field.Conclusion The molecular mechanism of TCM intervention in spinal cord injury is the current research hotspot.The target of TCM therapy for spinal cord injury for further elucidation,and clinical studies with higher evidence-based level for efficacy evaluation are the research trends in this field.
作者
张智龙
陈天鑫
杨胜平
朱瑜琪
ZHANG Zhilong;CHEN Tianxin;YANG Shengping;ZHU Yuqi(Ophthalmology Hospital,China Academy of Chinese Medical Sciences,Beijing 100040,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2024年第5期47-54,共8页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家中医药管理局中医药国际合作专项(中心类项目)(0610-2040NF020931、0610-2240NF0215)
中国中医科学院科技创新工程项目(CI2021A020)。
