摘要
目的:探究针药结合对阴虚体质和阳虚体质膝骨关节炎患者的疗效差异。方法:采用中央分层随机法将纳入的128例患者按照阴虚、阳虚体质的不同,再随机分为对照组、电针组、中药组、针药结合组。对照组除按需服用止痛药外不予干预,电针组予以电针治疗,中药组予以豨芍药对颗粒剂口服治疗,针药结合组予电针和豨芍药对颗粒剂口服,疗程均为4周,比较治疗前后西安大略和麦克马斯特大学骨关节炎指数(WOMAC)、膝关节肿胀度、视觉模拟量表(VAS)、广泛性焦虑障碍-7项量表(GAD-7)、匹兹堡睡眠质量指数(PSQI)、体质评分及血清中环磷酸腺苷(cAMP)/环磷酸鸟苷(cGMP)含量。结果:治疗后阴虚体质针药结合组WOMAC、V AS与体质评分均显著低于中药组(P<0.05),c AMP/c GMP较治疗前显著升高(P<0.05);阳虚体质电针组和针药结合组的WOMA C、VAS、体质评分均显著低于中药组(P<0.05),c AMP/c GMP较治疗前均显著升高(P<0.05)。结论:针刺结合中药豨芍药对可明显改善膝骨关节炎患者的症状,其中阴虚体质患者针药结合的疗效更优,而阳虚体质患者电针治疗与针药结合治疗疗效相近。
Objective:To explore the therapeutic effect difference of acupuncture combined with medicine for knee osteoarthritis with yin deficiency constitution and yang deficiency constitution.Methods:Using the central randomization method,128 patients were randomly divided into control group,electroacupuncture group,Chinese herb group and electroacupuncture combined with Chinese herb group,based on their different constitutions of yin deficiency and yang deficiency.The control group received no intervention except for taking painkillers as needed.The electroacupuncture group received electroacupuncture treatment,the Chinese herb group received oral treatment with Xi-Shao herb pair,and the combination group received electroacupuncture and herbal medicine orally.The treatment course was all 4 weeks.Western Ontario and McMaster universities osteoarthritis index(WOMAC),knee joint swelling,Visual Analog Scale(VAS),general anxiety disorder-7(GAD-7),Pittsburgh sleep quality index(PSQI),constitution score and serum cyclic adenosine monophosphate(cAMP)/cyclic guanosine monophosphate(cGMP)content were compared before and after treatment.Results:After treatment,in patients,the WOMAC,VAS,and constitution scores of the yin deficiency constitution combination group were lower than those of the Chinese herb group(P<0.05),and cAMP/cGMP increased compared to before treatment(P<0.05).The WOMAC,VAS,and constitution scores of the yang deficiency constitution electroacupuncture group and the combination group were lower than those of the Chinese herb group(P<0.05),and cAMP/cGMP increased compared to before treatment(P<0.05).Conclusion:Acupuncture combined with Chinese herb has an evident effect on patients with knee osteoarthritis,and electroacupuncture combined with Chinese herb is more effective for patients with yin deficiency constitution,while electroacupuncture treatment and electroacupuncture combined with Chinese herb treatment has similar effect for patients with yang deficiency constitution,both of which can significantly improve th
作者
李心怡
杨基举
吴阳
林怡
林海鸣
贺珂
田贵华
LI Xinyi;YANG Jiju;WU Yang;LIN Yi;LIN Haiming;HE Ke;TIAN Guihua(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2024年第4期2097-2102,共6页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
中共中央组织部国家高层次青年人才计划项目
国家中医药管理局青年岐黄学者支持项目。
关键词
电针
针药结合
豨芍药对
体质
阴虚
阳虚
膝骨关节炎
Electroacupuncture
Acupuncture combined with medicine
Xi-Shao herb pair
Constitution
Yin deficiency
Yang deficiency
Knee osteoarthritis(KOA)
