摘要
目的探讨温针灸联合中药熏蒸治疗膝关节骨性关节炎骨代谢指标及炎性因子的影响。方法选取医院收治的膝关节骨性关节炎患者134例,依据随机数字表法随机分为对照组和治疗组,各67例,对照组给予常规治疗,治疗组在对照组的基础上应用温针灸联合中药熏蒸对患者进行治疗,两组均进行为期1个月的治疗。观察两组患者VAS疼痛评分及膝关节功能指标WOMAC、Lysholm评分变化情况,比较两组骨代谢指标成纤维细胞生长因子2(FGF-2)、血清骨钙素(BGP)、降钙素(CT)、胰岛素样生长因子1(IGF-1)、骨保护素(OPG)及炎性因子基质金属蛋白酶3(MMP-3)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)治疗前后变化情况,治疗结束后计算两组的临床总有效率。结果两组治疗后VAS、WOMAC评分均明显下降(P<0.05),Lysholm评分明显上升(P<0.05),且治疗组较对照组各指标改善更显著(P<0.05);治疗后,治疗组FGF-2、BGP、IGF-1、OPG较治疗前有明显升高(P<0.05),CT较治疗前变化无统计学差异(P>0.05),对照组BGP、OPG较治疗前有明显上升(P<0.05),但FGF-2、CT、IGF-1较治疗前变化无统计学差异(P>0.05)。组间比较,治疗组FGF-2、BGP、IGF-1、OPG治疗后升高程度更显著,差异具有统计学意义(P<0.05)。两组患者治疗后炎性因子TNF-α、IL-1β、MMP-3均明显降低(P<0.05),且治疗组变化程度更为明显(P<0.05);治疗后,对照组临床总有效率为74.63%(50/67),治疗组临床总有效率为91.04%(61/67),治疗组的临床疗效优于对照组(P<0.05)。结论温针灸联合中药熏蒸治疗可以改善膝关节骨性关节炎患者临床症状,缓解疼痛,降低炎性因子,调节骨代谢指标,恢复膝关节功能,对于膝关节骨性关节炎有较好的的治疗效果,值得临床推广应用。
Objective The purpose of this study was to explore the effect of TCM fumigation therapy plus needle warming moxibustion on bonemetabolic markers and serum inflammatory factors of knee osteoarthritis.Methods Collected the information of knee osteoarthritis patients admitted to our hospital.PARTICIPANTS:134 patients were randomly divided into Control group(group A)and Treatment group(group B)according to the table of random number.Therapeutic Schedule:67 patients in the group A were treated with conventional treatment(Schedule A).67 patients in the group B were administered with TCM fumigation therapy combined with needle warming moxibustion plus Schedule A.treatmen course:1 month.Observed the changes of VAS scores,the Western Ontario McMaster(WOMAC)scores,and the Lysholm scores in the two groups.Compared the changes of bone metabolism indexes(including FGF-2,BGP,CT IGF-1,OPG)and serum inflammatory factors(including MMP-3,IL-1β,TNF-α)before and after treatment.After treatment,the total clinical effective rate of the two groups was calculated.Results After treatment,the VAS and WOMAC scores in both groups decreased(P<0.05),and the Lysholm scores increased(P<0.05).The indexes in the group B improved more significantly than group A(P<0.05).After treatment,the levels of FGF-2,BGP,IGF-1 and OPG in the group B were significantly higher than those before treatment(P<0.05),while the changes of CT had no statistical difference(P>0.05).The levels of BGP and OPG in the group A were significantly higher than those before treatment(P<0.05),but the changes of FGF-2,CT and IGF-1 had no statistical difference(P>0.05).Compared between groups,FGF-2,BGP,IGF-1 and OPG in the treatment group increased more significantly than the control group with statistical significance(P<0.05);After treatment,the inflammatory factors(such as TNF-α,IL-1β and MMP-3)in synovial fluid of the two groups were significantly decreased(P<0.05),and the change degree of the group B was more obvious(P<0.05).The clinical effect of the group B(91.04%,61/67)wa
作者
冯雷
邰东旭
FENG Lei;TAI Dongxu(The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)
出处
《辽宁中医杂志》
CAS
2022年第1期150-154,共5页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81372329)
国家中医药管理局中医药标准化项目(SATCM-2015-BZ)
辽宁省科学事业公益研究基金项目(GY2014-A-010)
关键词
中药熏蒸
温针灸
膝关节骨性关节炎
骨代谢指标
炎性因子
TCM fumigation
needle warming moxibustion
knee osteoarthritis
bonemetabolic markers
serum inflammatory factors
