摘要
IR的病理生理表现为靶组织和器官对Ins利用能力下降。IR致病因素有很多,表观遗传修饰改变是重要的调节机制。N6-甲基腺苷(m^(6)A)是真核生物mRNA中丰度较高的表观遗传修饰,其动态变化可调节相关酶表达,影响IR进程,在靶器官中发挥不同生物效应。本文综述m^(6)A甲基化对IR动态修饰及调控的研究进展。
Insulin resistance(IR)is an abnormal pathological and physiological process characterized by a decrease in the ability of target tissues and organs to utilize insulin.There are many factors related to IR.Epigenetic modification is one of the important regulatory mechanisms that cause IR.N6-methyladenosine(m^(6)A)is an epigenetic modification with high abundance in Eukaryote mRNA.Its dynamic changes can regulate the expression of related enzymes,affect IR process and exert different biological effects in target organs.This article reviews the research progress of dynamic modification and regulation of m^(6)A methylation in IR.
作者
蒋彩
胡悦
陈聪
JIANG Cai;HU Yue;CHEN Cong(College of Rehabilitation Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2024年第3期218-221,共4页
Chinese Journal of Diabetes
基金
国家自然科学基金(32271175)
福建省自然科学基金(2021J01960)。
