摘要
N^(6)-甲基腺苷(m 6A)修饰是真核生物mRNA中最常见的表观转录组修饰形式之一,具有动态可逆性。该修饰过程由甲基转移酶、去甲基化酶和与m 6A结合的蛋白质协同作用,影响mRNA的代谢和功能。越来越多的研究表明,m 6A RNA修饰在动脉粥样硬化(As)等多种疾病的发生和发展中扮演重要角色。文章综述了m 6A RNA修饰与As的关系。全文对m 6A RNA修饰机制以及在As相关细胞(如内皮细胞、巨噬细胞和平滑肌细胞)中的作用进行了全面总结,并探讨了m 6A RNA修饰与As危险因素,如高脂饮食、缺血缺氧、振荡应力及高血压的关联。最后,文章还对药物干预m 6A RNA甲基化以实现延缓As的研究进行了综述,为探索As早期诊断和治疗的新靶点提供了重要参考。
N^(6)-methyladenosine(m 6A)modification is one of the most abundant epitranscriptomic modifications in eukaryotic mRNA,with dynamic and reversible properties.This modification process is coordinated by methyltransferases,demethylases,and related m 6A binding proteins,which in turn affect mRNA metabolism and function.Increasing evidence has indicated that the m 6A RNA modification plays an important role in the occurrence and development of atherosclerosis(As)and other related diseases.This paper provide a comprehensive review of the relationship between m 6A RNA modification and As.The entire manuscript summarizes the m 6A RNA modification mechanism and its roles in As-related cells including endothelial cells,macrophages,and smooth muscle cells,and discusses the association of m 6A RNA modification with risk factors of As such as high-fat diet,ischemia/hypoxia,oscillatory stress,and hypertension.Finally,this review summarizes researches on drug intervention targeting m 6A RNA methylation to mitigate As.These studies provide important references for exploring new targets for early diagnosis and treatment of As.
作者
张晓璐
耿妙颖
王雲
蒙胜勇
王一婧
姜希娟
ZHANG Xiaolu;GENG Miaoying;WANG Yun;MENG Shengyong;WANG Yijing;JIANG Xijuan(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《中国动脉硬化杂志》
CAS
2024年第4期277-284,共8页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(82074211和81804025)
天津中医药大学中西医结合学院2019年度研究生创新基金项目(ZXYCXLX201902)。
