摘要
目的:研究谷氨酰胺与促红细胞生成素治疗坏死性小肠结肠炎早产儿的临床疗效及对患儿血清IL-6、TNFα、i-FABP水平的影响。方法:以回顾性分析法,采集自2020年1月至2022年1月于中国医科大学附属第一医院新生儿科确诊坏死性小肠结肠炎的早产患儿100例,根据患儿接受的治疗方法不同,分为观察组(n=50)与对照组(n=50)。观察组采用谷氨酰胺联合使用促红细胞生成素治疗,对照组采用单一谷氨酰胺治疗。记录并观察两组治疗总有效率、炎症反应、i-FABP、免疫球蛋白水平,肠道菌群变化,以及用药安全性。结果:观察组患儿的治疗总有效率(92.00%)明显高于对照组(70.00%),差异有统计学意义(P<0.05)。治疗前,两组患儿血清炎性因子、i-FABP、IgA、IgM、IgG水平以及粪便标本内肠道菌群差异无统计学意义(P>0.05);较治疗前,两组治疗7d后血清IL-6、TNF-α及i-FABP水平均下降,IgA、IgM、IgG水平、粪便标本中的细菌总数、球菌总数、杆菌总数均升高,差异有统计学意义(P<0.05);两组血清IL-6、TNF-α、i-FABP、IgA、IgM、IgG水平、粪便标本中的细菌总数、球菌总数、杆菌总数治疗前后差值比较,差异有统计学意义(P<0.05);随访一个月,组间不良反应差异无统计学意义(P>0.05)。结论:在谷氨酰胺基础上联合促红细胞生长素可有效提升坏死性小肠结肠炎早产患儿的临床疗效,降低血清炎性因子及i-FABP水平,促进早产儿肠道菌群稳定,增强患儿免疫力,且安全性较高。
Objective:To investigate the clinical efficacy of glutamine combined with erythropoietin in the treatment of necrotizing enterocolitis(NEC)in premature infants and its effect on serum IL-6,TNF-α,and i-FABP levels.Methods:A retrospective analysis was conducted on 100 premature infants diagnosed with NEC in the Department of Neonatology,The First Affiliated Hospital of China Medical University from January 2020 to January 2022.According to the treatment methods received by the infants,they were divided into the observation group(n=50)and the control group(n=50).The observation group was treated with glutamine combined with erythropoietin,and the control group was treated with glutamine alone.The total effective rate,inflammatory reaction,i-FABP,immunoglobulin level,intestinal flora change,and drug safety of the two groups were recorded and observed.Results:The total effective rate of the observation group(92.00%)was significantly higher than that of the control group(70.00%),and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the levels of serum inflamma-tory factors,i-FABP,IgA,IgM,IgG,and the total number of bacteria,cocci,and bacilli in the stool speci-mens between the two groups(P>0.05).Compared with before treatment,the levels of serum IL-6,TNF-αand i-FABP in both groups decreased after 7 days of treatment,and the levels of IgA,IgM,IgG,the total number of bacteria,cocci,and bacilli in the stool specimens increased.The differences were statistically sig-nificant(P<0.05).There was a statistically significant difference in the changes of serum IL-6,TNF-α,i-FABP,IgA,IgM,IgG levels,and the total number of bacteria,cocci,and bacilli in the stool specimens be-fore and after treatment between the two groups(P<0.05).During the one-month follow-up,there was no statistically significant difference in the adverse reactions between the two groups(P>0.05).Conclusion:On the basis of glutamine,combined erythropoietin can effectively improve the clini
作者
孙诗琦
朴倩
SUN Shiqi;PIAO Qian(The First Affiliated Hospital of China Medical University,Liaoning Shenyang 110001,China)
出处
《河北医学》
CAS
2024年第4期682-687,共6页
Hebei Medicine
基金
辽宁省教育厅2021年度科学计划项目(编号:2101A1030)。
