摘要
目的:探讨极早产儿发生输血相关性坏死性小肠结肠炎(TA-NEC)的危险因素。方法:以枣阳市妇幼保健院2015年1月—2023年1月收治的接受红细胞输注治疗的200例极早产儿为研究对象,其中TA-NEC患儿共100例纳入研究组,无坏死性小肠结肠炎(NEC)患儿共100例纳入对照组。比较研究对象的一般临床资料、不良情况发生率、输血情况、末次输血前并发症情况,采用logistic多因素回归分析TA-NEC发生的危险因素。结果:两组胎龄、出生体重、性别、输血日龄、1 min阿普加(Apgar)评分等一般临床资料比较,差异无统计学意义(P>0.05)。研究组宫内窘迫发生率为23.00%,绒毛膜羊膜炎发生率为40.00%,均高于对照组的8.00%、20.00%,差异有统计学意义(P<0.05);研究组末次输血前血红蛋白(Hb)水平明显低于对照组,差异有统计学意义(P<0.05);研究组凝血功能异常、重症肺炎、晚发型败血症发生率高于对照组,差异有统计学意义(P<0.05)。logistic多因素分析显示,极早产儿发生TA-NEC的危险因素主要包括宫内窘迫、绒毛膜羊膜炎、晚发型败血症(P<0.05)。结论:极早产儿发生TA-NEC主要与宫内窘迫、绒毛膜羊膜炎、晚发型败血症等因素有关。临床上在对极早产儿进行输血治疗时应对以上因素进行充分考虑,并在此基础上对红细胞输血策略进行合理制订,从而实现对TA-NEC的有效预防,改善极早产儿预后。
Objective:To explore the risk factors of transfusion associated necrotizing enterocolitis(TA-NEC)in extremely premature infants.Method:A total of 200 extremely premature infants who received red blood cell infusion treatment at Zaoyang Maternal and Child Health Care Hospital from January 2015 to January 2023 were selected as the study subjects.Among them,100 TA-NEC children were included in the study group,and 100 non necrotizing enterocolitis(NEC)children were included in the control group.The general clinical data,incidence of adverse events,blood transfusion situation and complications before the last blood transfusion of the study subjects were compared,and logistic multiple factor regression analysis was used to identify the risk factors for TA-NEC.Result:There were no statistically significant differences in general clinical data such as gestational age,birth weight,gender,blood transfusion age,and 1 minute Apgar score between the two groups(P>0.05).The incidence of intrauterine distress in the study group was 23.00%,and the incidence of chorioamnionitis was 40.00%,which were higher than 8.00%and 20.00%in the control group,the differences were statistically significant(P<0.05).The hemoglobin(Hb)level before the last blood transfusion in the study group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).The incidence of abnormal coagulation function,severe pneumonia,and late onset sepsis in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).logistic multivariate analysis showed that the risk factors for TA-NEC in extremely premature infants mainly include intrauterine distress,chorioamnionitis,and late onset sepsis(P<0.05).Conclusion:The occurrence of TA-NEC in extremely premature infants is mainly related to factors such as intrauterine distress,chorioamnionitis,and late onset sepsis.In clinical practice,the above factors should be fully considered when conducting blood transfusion tr
作者
姜宁
JIANG Ning(Zaoyang Maternal and Child Health Care Hospital,Zaoyang 441299,China)
出处
《中外医学研究》
2023年第15期105-108,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
极早产儿
输血相关性
坏死性小肠结肠炎
危险因素
Extremely premature infants
Blood transfusion correlation
Necrotizing enterocolitis
Risk factors
