摘要
目的:探讨溃疡性结肠炎(UC)患者肠道菌群特征及IL-23/IL-17表达与幽门螺杆菌(Hp)感染的相关性。方法:选取2020年8月至2023年8月我科收治的70例UC患者(UC组)和同期健康体检者70名(健康对照组,即HC组)为研究对象,比较UC组和HC组肠道菌群、IL-17、IL-23水平及Hp感染情况。同时,根据是否伴有Hp感染将UC组患者分为Hp阳性UC组(30例)和Hp阴性UC组(40例),比较Hp阳性UC组和Hp阴性UC组患者肠道菌群、IL-17及IL-23水平,并应用Spearman相关和Logistic回归分析肠道菌群、IL-17、IL-23与UC患者Hp感染的相关性。结果:UC组大肠埃希菌、IL-17、IL-23水平高于HC组,长双歧杆菌水平低于HC组(P<0.05);而嗜酸乳杆菌2组比较无明显差异(P>0.05)。UC组Hp感染率(42.86%)低于HC组(65.71%)(P<0.05);Hp阳性UC组长双歧杆菌水平高于Hp阴性UC组,IL-17、IL-23水平低于Hp阴性UC组(P<0.05),而嗜酸乳杆菌、大肠埃希菌2组比较无明显差异(P>0.05)。Spearman分析显示,IL-17及IL-23与UC Hp感染呈负相关(r=-0.733、-0.836,P<0.05),与长双歧杆菌呈正相关(r=0.367,P<0.05);Logistic回归分析显示,长双歧杆菌、IL-17、IL-23是UC Hp感染的独立相关因素(P<0.05)。结论:UC患者肠道菌群分布状态和IL-23、IL-17表达异常与其Hp感染关系密切。
Objective To investigate the correlation of intestinal flora characteristics and IL-23/IL-17expression in ulcerative colitis(UC)patients with Helicobacter pylori(Hp)infection.Methods Total 70 UC patients(UC group)admitted to our department from August 2020to August 2023and 70healthy people(healthy control group,HC group)in the same period were selected as the study objects.The intestinal flora,IL-17,IL-23levels and Hp infection of UC group and HC group were compared.At the same time,the UC group was divided into Hp positive UC group(30cases)and Hp negative UC group(40cases)according to whether they were accompanied by Hp infection.The intestinal flora,IL-17and IL-23levels of patients in Hp positive UC group and Hp negative UC group were compared.Spearman correlation and Logistic regression were used to analyze the correlation between intestinal flora,IL-17,IL-23and Hp infection in UC patients.Results The levels of Escherichia coli,IL-17and IL-23in the UC group were higher than those in the HC group,and the level of bifidobacteria longum in the UC group was lower than that in the HC group(P<0.05).There was no significant difference in Lactobacillus acidophilus between the two groups(P>0.05).The Hp infection rate in the UC group(42.86%)was lower than that in the HC group(65.71%)(P<0.05).The level of bifidobacteria longum in Hp positive UC group was higher than that in Hp negative UC group,and the levels of IL-17and IL-23in Hp positive UC group were lower than those in Hp negative UC group(P<0.05).There was no significant difference in Lactobacillus acidophilus and Escherichia coli between the two groups(P>0.05).Spearman analysis showed that IL-17 and IL-23were negatively correlated with Hp infection in UC(r=-0.733,-0.836,P<0.05),and positively correlated with bifidobacteria longum(r=0.367,P<0.05).Logistic regression analysis showed that bifidobacteria longum,IL-17and IL-23were independent factors for Hp infection in UC(P<0.05).Conclusion The distribution of intestinal flora and abnormal expression of IL-23and IL-17
作者
张海桢
成源源
何泉
ZHANG Hai-zhen;CHENG Yuan-yuan;HE Quan(Department of Gastroenterology,Shangqiu Fourth People's Hospital,Shangqiu,Henan 476000)
出处
《中国肛肠病杂志》
2024年第2期36-39,共4页
Chinese Journal of Coloproctology
