摘要
肺衰老是由机体衰老进程(年龄增长)和(或)内外有害环境作用所引起的肺部衰老性变化。吸烟可通过端粒缩短、线粒体功能障碍、蛋白稳态失衡、表观遗传改变、DNA损伤修复异常和细胞外微环境失调等病理改变促进肺衰老,并参与多种慢性呼吸系统疾病的发生发展。本文从气道上皮、肺泡上皮、血管内皮、成纤维细胞和免疫细胞角度,对吸烟在肺衰老中的作用进行总结。
Lung aging is an aging change in the lungs caused by the aging process of the body and/or internal and external harmful environmental factors.Cigarette smoke aggravates lung aging through pathological changes like telomere reduction,mitochondrial dysfunction,protein homeostasis imbalance,epigenetic changes,DNA damage repair abnormalities,and extracellular microenvironment disorders.It participates in the occurrence and development of a variety of chronic respiratory diseases.This article summarizes the role of cigarette smoke in lung aging from the perspectives of airway epithelium,alveolar epithelium,vascular endothelium,fibroblasts,and immune cells.
作者
林佳宁
谢明萱
蒋晨
戴子喻
陈琼
Lin Jianing;Xie Mingauan;Jiang Chen;Dai Ziyu;Chen Qiong(Department of Geriatric Pulmonary and Critical Care Medicine,National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha 410008,China)
出处
《国际呼吸杂志》
2024年第3期267-271,共5页
International Journal of Respiration
基金
国家自然科学基金(82370055)。
关键词
细胞衰老
吸烟
呼吸道疾病
表观基因组学
Cellular senescence
Smoking
Respiratory tract diseases
Epigenomics
