摘要
胃癌(GC)发生与基因和表观遗传改变密切相关。非编码RNA(ncRNA)间的竞争性内源性调控,间接影响下游靶基因的表达,与GC的恶性生物学行为密切相关。深入研究ncRNA调控GC相关基因的表达,为GC的早期诊断和寻找预后标志物提供了可能。本文综述了近年来在GC中发现的ncRNA间的竞争性内源性调控,为GC的早期诊断、生物标志物的开发和应用提供一种新的思路或策略。
Gastric carcinoma occurrence is strongly associated with genetic and epigenetic changes.The competitive endogenous regulation between non-coding RNA(ncRNA)indirectly affects the expression of downstream target genes and is closely related to the malignant biology of GC.Further studies of ncRNA-mediated expression of gastric-cancer-related genes may facilitate early diagnosis of GC and the search of prognostic markers.This review summarizes the recent discovery of competing endogenous regulation among ncRNA in GC,providing a new approach or strategy for early diagnosis,biomarker development,and application.
作者
李彬彬
肖娟
伍石华
曾雪梅
张志伟
LI Bingbing;XIAO Juan;WU Shihua;ZENG Xuemei;ZHANG Zhiwei(Cancer Research Institute,School of Basic Medicine,the Second Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang 421001,Hunan,China;Department of Head and Neck Surgery,the Second Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang 421001,Hunan,China;Department of Pathology,the Second Affiliated Hospital,Shaoyang University,Shaoyang 422000,Hunan,China)
出处
《中南医学科学杂志》
CAS
2024年第1期138-141,共4页
Medical Science Journal of Central South China
基金
国家重点研发计划项目子课题(2021YE0192100)
湖南省自然科学基金项目(2023JJ30529)
湖南省自然科学省市联合基金(2022JJ50029)
湖南省临床医疗技术创新引导项目(2020SK51703)
湖南省教育厅重点项目(21A0285)
邵阳市科技局重点项目(2021GZ031)。
关键词
胃癌
非编码RNA
竞争性内源性调控
基因表达
gastric cancer
non-coding RNA
competing endogenous regulation
gene expression
