摘要
目的探讨替加环素辅助治疗多重耐药鲍曼不动杆菌(AB)肺炎患者的临床效果。方法112例多重耐药AB肺炎患者随机分为两组,对照组给予头孢哌酮舒巴坦治疗,观察组在对照组基础上给予替加环素治疗,比较两组的治疗效果。结果治疗后,观察组的总有效率、细菌清除率均高于对照组,WBC、CRP、PCT水平均低于对照组(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论替加环素辅助治疗多重耐药AB肺炎患者可提高疗效,减轻机体炎性反应,提高细菌清除率。
Objective To explore the clinical effect of tigecycline in the adjuvant treatment of patients with multidrug-resistant Acinetobacter Baumanni(AB)pneumonia.Methods 112 patients with multidrug-resistant AB pneumonia were randomly divided into two groups.The control group was treated with cefoperazone sulbactam,and the observation group was treated with tigecycline on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the total effective rate and bacterial clearance rate of the observation group were higher than those of the control group,and the levels of WBC,CRP,and PCT were lower than those of the control group(P<0.05).No significant difference was found in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Tigecycline in the adjuvant treatment of patients with multidrug-resistant AB pneumonia can improve the therapeutic effect,alleviate the inflammatory response of the body,and increase the bacterial clearance rate.
作者
崔宝月
李震
孙源彬
范娟
CUI Baoyue;LI Zhen;SUN Yuanbin;FAN Juan(Department of Clinical Pharmacy,Nanyang Second People's Hospital,Nanyang 473000,China;Department of Respiratory Medicine,Nanyang Second People's Hospital,Nanyang 473000,China;Microbiology Room,Nanyang Second People's Hospital,Nanyang 473000,China;Hospital Infection Office,Nanyang Second People's Hospital,Nanyang 473000,China)
出处
《临床医学工程》
2024年第4期439-440,共2页
Clinical Medicine & Engineering
关键词
多重耐药鲍曼不动杆菌肺炎
替加环素
头孢哌酮舒巴坦
炎性因子
Multidrug-resistant Acinetobacter Baumanni pneumonia
Tigecycline
Cefoperazone sulbactam
Inflammatory factor
