摘要
蛋白质糖基化是最常见的蛋白质翻译后修饰(post-translational modification,PTM)之一,其广泛存在于生命体中。真核细胞中,糖基化修饰对蛋白质的折叠、构象、分布、稳定性和活性具有重要的影响。研究表明,糖蛋白的糖链对于维持多细胞生物所有分化细胞间相互作用的秩序至关重要。蛋白质糖基化的功能障碍可能导致疾病的发生和感染性疾病的发展。迄今已有许多蛋白质的N/O-聚糖改变被确定为肿瘤和某些传染性疾病发展的生物标志物。因此,本文针对B细胞受体(B-cell receptor,BCR)、T细胞受体(T-cell receptor,TCR)、细胞因子(cytokines,CK)、补体(complement)和免疫球蛋白(immunoglobulin,Ig)等主要的免疫分子的糖基化修饰,以及相关糖基化修饰与传染性疾病之间的关系进行综述,旨在阐释免疫分子的糖基化与传染性疾病之间的关联,为治疗感染性疾病提供新思路和策略。
Protein glycosylation,one of the most common post translational modifications(PTMs)of proteins,is widely present in living organisms.In eukaryotic cells,glycosylation modifications have a significant impact on protein folding,conformation,distribution,stability and activity.The glycosylation of glycoproteins is crucial for maintaining the order of interactions between all differentiated cells in multicellular organisms.The dysfunction of protein glycosylation may lead to the occurrence of diseases and development of infectious diseases.So far,changes in protein N/O-glycan have been identified as biomarkers for the development of tumors and certain infectious diseases.Therefore,this article reviews the glycosylation of major immune molecules such as B-cell receptor(BCR),T-cell receptor(TCR),cytokines(CK),complement and immunoglobulin(Ig),as well as the relationship between these glycosylation and infectious diseases.The aim is to understand the association between glycosylation of immune molecules and infectious diseases,and to provide new ideas and strategies for the treatment of infectious diseases.
作者
方丹
章晓联
FANG Dan;ZHANG Xiao-Lian(Department of Immunology,Wuhan University TaiKang Medical School(School of Basic Medical Sciences),Wuhan 430071;Hubei Province Key Laboratory of Allergy and Immunology,Wuhan 430071)
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2024年第4期484-492,共9页
Chinese Journal of Biochemistry and Molecular Biology
基金
“十四五”国家重点研发计划项目(No.2022YFA1303500)
国家自然科学基金重点项目和面上项目(No.82230078,No.22077097)。
关键词
宿主免疫分子
糖基化
感染性疾病
host immune molecules
glycosylation
infectious diseases
