摘要
目的 研讨采用阿奇霉素序贯疗法联合甲泼尼龙治疗儿童支原体肺炎的临床效果。方法 针对2019年11月至2023年12月期间,在我院接受治疗感染支原体肺炎的儿童120例,数字表法随机分为成2组,即60例对照组和60例实验组,对照组患病儿童治疗方案为阿奇霉素序贯疗法,实验组患病儿童治疗方案采取阿奇霉素联合甲泼尼龙,分析和对比不同分组患病儿童的疗效、发生不良反应、炎性因子[反应蛋白(CrP)、降钙素原(PCT)、白介素-10(IL-10)]、通气状况[动脉氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、动脉氧饱和度(SaO_(2))]、免疫血球素[IgA、IgG、IgM]的差异。结果 对照组患病儿童的治疗有效率达86.7%,实验组患病儿童治疗有效率达98.3%(P<0.05),不良反应方面数据显示,实验组患病儿童比对照组患病儿童优势很明显(P<0.05)。炎症因子:治疗后,对照和实验两组儿童炎症因子的指标值都下降显著PCT(P=0.036),CRP(P=0.047),IL-10(P=0.048)(P<0.05),实验组患病儿童CRP、IL-10、PCT炎症因子明显要比对照组更低。通气状况:治疗后,对照和实验两组儿童PaO_(2)和SaO_(2)要比治疗前高,PaCO_(2)要比治疗前低,而且实验组明显要比对照组好。免疫血球素:治疗后,对照和实验两组儿童IgA、IgM、IgG要比治疗前高,而且实验组明显要比对照组好。结论 采用阿奇霉素序贯疗法联合甲泼尼龙在儿童感染支原体肺炎临床治疗中能起到更好疗效,能很大程度上缩短患病儿童的康复时间、比较安全,治疗方式值得临床上加以推广。
Objective To explore the clinical effect of sequential therapy with azithromycin combined with methylprednisolone in the treatment of Mycoplasma pneumonia in children.Methods A total of 120 children who received treatment for Mycoplasma pneumonia in our hospital from November 2019 to December 2023 were randomly divided into two groups using the number table method:a control group of 60 cases and an experimental group of 60 cases.The control group received sequential treatment with azithromycin,while the experimental group received treatment with azithromycin combined with methylprednisolone.The therapeutic effects,adverse reactions,and outcomes of different groups of affected children were analyzed and compared Differences in inflammatory factors[reactive protein(CrP),procalcitonin(PCT),interleukin-10(IL-10)],ventilation status[arterial oxygen pressure(PaO_(2)),arterial carbon dioxide pressure(PaCO_(2)),arterial oxygen saturation(SaO_(2))],and immunoglobulins[IgA,IgG,IgM].Results The effective rate of treatment for the control group of sick children was 86.7%,while the effective rate of treatment for the experimental group of sick children was 93.3%,P<0.05.Data on adverse reactions showed that the experimental group of sick children had a significant advantage over the control group of sick children,P<0.05.Inflammatory factors:After treatment,the index values of inflammatory factors in both the control and experimental groups of children decreased significantly(P<0.05).The CRP,IL-10,and PCT inflammatory factors in the experimental group of sick children were significantly lower than those in the control group.Ventilation status:After treatment,the PaO_(2) and SaO_(2) of the control and experimental groups of chil-dren were higher than before treatment,and the PaCO_(2) was lower than before treatment,and the experimental group was significantly better than the control group.Immunoglobulin:After treatment,The levels of IgA,IgM and IgG in the control and experimental groups were higher than before treatment,and the
作者
赵莉
Zhao Li(Department of Pediatrics,Shanyang County Traditional Chinese Medicine Hospital,Shangluo City,Shanxi,726400,China)
出处
《青岛医药卫生》
2024年第2期93-96,共4页
Qingdao Medical Journal
关键词
阿奇霉素序贯疗法
支原体肺炎
甲泼尼龙琥珀酸
治疗疗效
Azithromycin sequential therapy
Mycoplasma pneumonia
Methylprednisolone suc-cinic acid
Therapeutic efficacy
