摘要
目的通过系统评价探讨COVID-19患者病情的严重程度与实验室特征的关系。方法检索PubMed、Embase、Cochrane Library、中国知网、万方和维普数据库收集符合纳入标准的文献,质量评价采用QUADAS-2工具完成,数据荟萃分析采用Review Manager 5.3软件进行。结果共纳入25项研究,涉及3741例研究对象(其中轻度/中度2520例,重度/危重1221例)。相比轻度/中度患者,重度/危重患者的白细胞、中性粒细胞、谷丙转氨酶、谷草转氨酶、总胆红素、肌酐、C反应蛋白、乳酸脱氢酶、降钙素原、D-二聚体和纤维蛋白原显著升高。淋巴细胞、白蛋白、CD3+T、CD4+T和CD8+T显著降低。血小板、血红蛋白和CD4/CD8比值的变化无明显差异。结论血常规、肝肾功能标志物、炎症/感染标志物、凝血功能等实验室特征与COVID-19患者病情严重程度密切相关。
Objective To explore the relationship between disease severity and laboratory characteristics of COVID-19 patients through systematic review.Methods References met the inclusion criteria were retrieved from PubMed,Embase,Cochrane Library,CNKI,Wanfang Data and VIP databases.The quality evaluation was completed by QUADAS-2 tool,data meta-analysis was performed by Review Manager 5.3 software.Results A total of 25 studies were included,involving 3741 research subjects(2520 mild/moderate cases and 1221 severe/critical cases).Compared with mild/moderate patients,leukocytes,neutrophils,alanine aminotransferase,aspartate aminotransfer-ase,total bilirubin,creatinine,C-reactive protein,lactate dehydrogenase,procalcitonin,D-dimer and fibrinogen were significantly increased in severe/critical patients.Lymphocytes,albumin,CD3+T,CD4+T and CD8+T were significantly decreased.There were no significant difference in the change of platelet,hemoglobin and CD4/CD8 ratio.Conclusions Laboratory characteristics of blood routine examination,markers of liver and kidney function,markers of inflammation/infection and coagulation function are closely related to the severity of COVID-19 patients.
作者
李欢
方绕红
李海龙
张智雄
张世德
LI Huan;FANG Raohong;LI Hailong;ZHANG Zhixiong;ZHANG Shide(Department of Laboratory Medicine,Southern Central Hospital of Yunnan Province/First People’s Hospital of Honghe Prefecture,Honghe Yunnan 661100,China)
出处
《云南医药》
CAS
2024年第2期52-57,共6页
Medicine and Pharmacy of Yunnan
