摘要
目的分析新型冠状病毒肺炎(COVID-19)患者实验室部分指标与病情严重程度的关系。方法收集2020年1月—3月武汉大学中南医院COVID-19患者实验室检查结果,比较COVID-19轻型及普通型(普通组)和重型及危重型(重症组)患者血常规、D-二聚体(DD)、C-反应蛋白(CRP)、降钙素原(PCT)、血清淀粉样蛋白A(SAA)、细胞因子以及淋巴细胞亚群等指标。采用Logistic回归分析实验室指标与病情严重程度的关系。结果重症组患者白细胞(WBC)计数、中性粒细胞百分比(NEUT%)、中性粒细胞/淋巴细胞比值(NLR),炎症指标SAA、CRP、PCT、DD、白细胞介数(IL)-6、IL-10均高于普通组患者(P<0.05),而淋巴细胞百分比(LYMPH%)明显低于普通组患者(P<0.05);重症组患者平均红细胞体积(MCV)、红细胞分布宽度(RDW)、血红蛋白(Hb)、血小板(PLT)计数、肿瘤坏死因子-α(TNF-α)、IL-2和IL-4与普通组患者无统计学差异(P>0.05);重症组患者淋巴细胞总数显著低于普通组患者(P<0.05),但重症组和普通组患者淋巴细胞构成无统计学差异(P>0.05)。Logistic回归分析发现,WBC计数、NEUT%、NLR、SAA、DD、CRP、IL-6和IL-10均能作为反映COVID-19病情严重程度的实验室指标(P<0.05)。结论重型及危重型COVID-19患者WBC计数、NEUT%、NLR、SAA、DD、CRP、IL-6和IL-10较轻型及普通型患者有明显变化,这些指标的变化有助于及早判断病情发展趋势。
Objective To study the correlation between some laboratory indexes and severity of corona virus disease 2019(COVID-19).Methods The results of laboratory examination of 144 patients with COVID-19 confirmed in Zhongnan Hospital of Wuhan University from January 20,2020 to March 10,2020 were collected and analyzed retrospectively.The blood routine examination,D-dimer(DD),C-reactive protein(CRP),procalcitonin(PCT),serum amyloid A protein(SAA),cytokines and lymphocyte subgroups were compared between common and severe COVID-19 patients.Logistic regression was used to analyze the relationship between laboratory indexes and COVID-19 severity.Results Severe patients had higher levels of white blood cell(WBC)count,neutrophil percentage(NEUT%),neutrophil/lymphocyte ratio(NLR),SAA,CRP,PCT,DD,interleukin(IL)-6 and IL-10 than commonpatients(P<0.05).Lymphocyte percentage(LYMPH%)was significantly lower in severe group than that in common group(P<0.05).There was no significant difference in mean corpuscular volume(MCV),red blood cell volume distribution width(RDW),hemoglobin(Hb),platelet(PLT)count,tumor necrosis factor alpha(TNF-α),IL-2 or IL-4 between the two groups(P>0.05).The total lymphocyte number was significantly lower in severe group than that in common group(P<0.05),but no significant difference was found in the lymphocyte constituent ratio between the two groups(P>0.05).Logistic regression analysis showed that WBC count,NEUT%,NLR,SAA,DD,CRP,IL-6 and IL-10 could be used as laboratory indexes to reflect the severity of COVID-19(P<0.05).Conclusion WBC count,NEUT%,NLR,SAA,DD,CRP,IL-6 and IL-10 in severe COVID-19 patients have obvious changes as compared with those in common patients.The changes of these laboratory indexes are helpful for the early diagnosis of COVID-19.
作者
廖生俊
徐献群
赵瑾
黎四维
邱雪平
陈良君
李一荣
LIAO Shengjun;XU Xianqun;ZHAO Jin;LI Siwei;QIU Xueping;CHEN Liangjun;LI Yirong(Department of Clinical Laboratory,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei,China)
出处
《检验医学》
CAS
2021年第1期48-52,共5页
Laboratory Medicine
