摘要
目的探讨小柴胡汤联合针刺治疗痞证的临床效果。方法选取2021年5月至2023年6月濮阳市中医医院60例痞证患者,随机分为两组,各30例。两组均接受常规治疗,于此基础上,对照组接受针刺治疗,观察组接受小柴胡汤联合针刺,均连续治疗4周。比较两组临床疗效、中医证候积分、胃肠激素[生长抑素(SS)、胃泌素(GAS)、胃动素(MOT)]、LPS/TLR4/NF-κB通路相关因子[内毒素(LPS)、Toll样受体4(TLR4)、核因子-κB(NF-κB)],并评估安全性。结果观察组临床总有效率高于对照组(P<0.05);治疗2周及4周,观察组主症、次症及总积分较对照组低(P<0.05);治疗2周及4周,观察组GAS、MOT较对照组高,SS较对照组低(P<0.05);治疗2周及4周,观察组LPS、TLR4、NF-κB水平较对照组低(P<0.05);治疗期间两组均未发生明显不良反应。结论小柴胡汤联合针刺可能通过调节LPS/TLR4/NF-κB通路缓解痞证临床症候,调节胃肠激素与功能,治疗效果显著,可改善生活质量。
Objective To explore the clinical effect of Xiaochaihu decoction combined with acupuncture in treating syndrome of fullness and oppression.Methods A total of 60 patients with cirrhosis in Chinese Medicine Hospital of Puyang from May 2021 to June 2023 were randomly divided into two groups,with 30 cases in each group.Both groups were given routine treatment.On this basis,the control group received acupuncture treatment,and the observation group received Xiaochaihu decoction combined with acupuncture treatment,both of which were treated continuously for 4 weeks.The clinical efficacy,TCM syndrome scores,main frequency and amplitude of electrogastrogram,gastrointestinal hormones[somatostatin(SS),gastrin(GAS),motilin(MOT)],LPS/TLR4/NF-κB pathway related factors[lipopolysaccharides(LPS),Toll-like receptor 4(TLR4),nuclear factor-κB(NF-κB)]were compared between the two groups,and safety was evaluated.Results The total clinical effective rate in the observation group was higher than that in the control group(P<0.05).After 2 and 4 weeks of treatment,the main symptoms,secondary symptoms and total score of the observation group were lower than those of the control group(P<0.05).After 2 and 4 weeks of treatment,the observation group showed higher levels of GAS and MOT compared to the control group,and lower levels of SS compared to the control group(P<0.05).Treatment for 2 and 4 weeks,LPS,TLR4,NF-κB level of observation group was lower than that of the control group(P<0.05).During the treatment period,neither group experienced significant adverse reactions.Conclusion Xiaochaihu decoction combined with acupuncture may relieve the clinical symptoms of edema,regulate gastrointestinal hormone and function by regulating LPS/TLR4/NF-κB pathway,and the therapeutic effect is significant,which can improve the quality of life.
作者
孙玮琦
张晓玉
曹静静
刘同坤
SUN Weiqi;ZHANG Xiaoyu;CAO Jingjing;LIU Tongkun(Rehabilitation Department,Chinese Medicine Hospital of Puyang,Puyang 457000,China;Department of Traditional Chinese Medicine,Chinese Medicine Hospital of Puyang,Puyang 457000,China;Rehabilitation Department,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《河南医学研究》
CAS
2024年第7期1321-1324,共4页
Henan Medical Research
