摘要
目的:观察调Q激光联合氨甲环酸治疗红斑毛细血管扩张型玫瑰痤疮(Erythematous telangiectasia rosacea,ETR)的疗效。方法:选取2022年9月-2023年6月武汉中南医院收治的90例ETR患者,采用随机数字表法分为三组,每组30例。对照1组采用修护保湿霜,同时予以氨甲环酸湿敷治疗;对照2组采用强脉冲光(Intense pulsed light,IPL),同时予以氨甲环酸湿敷治疗;实验组采用调Q激光,同时予以氨甲环酸治疗。比较三组持续性红斑评估量表(Clinician’s erythema assessment,CEA)、丘疹脓疱研究者整体评估分级量表(Investigator’s global assessment,IGA)、临床疗效、皮肤屏障功能、生活质量[痤疮特异性生活质量问卷(Acne-Quality of Life,Acne-QoL)]和不良反应。结果:治疗后,三组CEA和IGA评分均降低,实验组<对照2组<对照1组,两两对比差异有统计学意义(均P<0.05)。实验组临床总有效率(96.67%)>对照2组(80.00%)>对照1组(53.33%),两两对比差异有统计学意义(均P<0.05)。治疗后,三组皮肤含水量、表皮皮脂含量均增加,实验组>对照2组>对照1组,三组经皮水分流失量均减少,实验组<对照2组<对照1组,两两对比差异有统计学意义(均P<0.05)。治疗后,三组Acne-QoL评分中的自我感知、情感功能、社会功能和痤疮症状等各维度评分均升高,实验组>对照2组>对照1组,两两对比差异有统计学意义(均P<0.05)。三组均未发生明显的不良反应。结论:调Q激光联合氨甲环酸治疗ETR可提高临床疗效,并能够减轻皮损症状,修复皮肤屏障功能,提高患者生活质量,安全可靠。
Objective To observe the efficacy of Q-switched laser combined with tranexamic acid in the treatment of erythema telangiectasia rosacea(ETR).Methods 90 cases ETR patients admitted to Zhongnan hospital of Wuhan university from September 2022 to June 2023 were selected and divided into 3 groups using a random number table method,with 30 patients in each group.The control 1 group was treated with repair and moisturizing cream+tranexamic acid wet compress,the control 2 group was treated with intense pulsed light(IPL)+tranexamic acid wet compress,the experimental group was treated with Q-switched 1064 nm laser+tranexamic acid wet compress.The clinician's erythema assessment(CEA),investigator’s global assessment(IGA),clinical efficacy,skin barrier function,Acne-Quality of Life(Acne QoL score)and adverse reactions in 3 groups were compared.Results After treatment,the CEA and IGA in 3 groups were all reduced,with a trend of the experimental group<control 2 group<control 1 group(P<0.05).The total clinical effective rate showed a trend of the experimental group(96.67%)<control 2 group(80.00%)<control 1 group(53.33%)(P<0.05).After treatment,the skin water content and epidermal sebum content of 3 groups increased,with a trend of experimental group>control 2 group>control 1 group(P<0.05).The loss of percutaneous water diversion in 3 groups decreased,with a trend of experimental group<control 2 group<control 1 group(P<0.05).After treatment,the scores of self perception,emotional function,social function and acne symptoms in the Acne QoL scores of 3 groups all increased,with a trend of experimental group>control 2 group>control 1 group(P<0.05).There were no serious adverse reactions happened in 3 groups.Conclusion The Q-switched laser combined with tranexamic acid can be used in the treatment of ETR,by improving clinical efficacy,alleviating skin lesion symptoms,repairing skin barrier function,improving quality of life,which is safe and reliable.
作者
萧瑜晔
宋继权
谢君
HSIAO Yuyeh;SONG Jiquan;XIE Jun(Department of Dermatology,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei,China)
出处
《中国美容医学》
CAS
2024年第4期83-87,共5页
Chinese Journal of Aesthetic Medicine
