摘要
目的探讨可溶性白细胞分化抗原14亚型(sCD14-ST)联合白细胞介素-6(IL-6)对细菌性呼吸道感染患儿的诊断价值。方法选取2021年4月至2022年4月该院收治的55例细菌性呼吸道感染患儿作为观察组,另选取同期在该院健康体检的55例儿童作为对照组。检测并比较两组sCD14-ST、IL-6水平,采用Pearson相关分析细菌性呼吸道感染患儿sCD14-ST水平与IL-6水平的相关性,采用多因素Logistic回归分析儿童发生细菌性呼吸道感染的危险因素,绘制受试者工作特征曲线分析血清sCD14-ST、IL-6对儿童发生细菌性呼吸道感染的诊断价值。结果观察组血清sCD14-ST、IL-6水平均高于对照组,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,细菌性呼吸道感染患儿血清sCD14-ST水平与IL-6水平呈正相关(r=0.422,P=0.001)。多因素Logistic回归分析结果显示,sCD14-ST>443.82 pg/mL、IL-6>13.75 pg/mL是儿童发生细菌性呼吸道感染的独立危险因素(P<0.05)。2项指标联合诊断儿童发生细菌性呼吸道感染的曲线下面积为0.887(95%CI:0.741~0.975),灵敏度为90.91%,特异度为80.00%。结论sCD14-ST>443.82 pg/mL、IL-6>13.75 pg/mL是儿童发生细菌性呼吸道感染的独立危险因素,2项指标联合检测能提高对儿童发生细菌性呼吸道感染的诊断价值。
Objective To investigate the diagnostic value of soluble leukocyte differentiation antigen 14 subtype(sCD14-ST)combined with interleukin-6(IL-6)in children with bacterial respiratory tract infection.Methods A total of 55 children with bacterial respiratory tract infection admitted to the hospital from April 2021 to April 2022 were selected as the observation group,and 55 healthy children who underwent physical examination in the hospital during the same period were selected as the control group.The levels of sCD14-ST and IL-6 were detected and compared between the two groups.Pearson correlation analysis was used to analyze the correlation between sCD14-ST level and IL-6 level in children with bacterial respiratory tract infection.Multivariate Logistic regression analysis was used to analyze the risk factors of children with bacterial respiratory tract infection.The receiver operating characteristic curve was drawn to analyze the diagnostic value of serum sCD14-ST and IL-6 in children with bacterial respiratory tract infection.Results The serum levels of sCD14-ST and IL-6 in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that serum sCD14-ST level was positively correlated with IL-6 level in children with bacterial respiratory tract infection(r=0.422,P=0.001).Multivariate Logistic regression analysis showed that sCD14-ST>443.82 pg/mL and IL-6>13.75 pg/mL were independent risk factors for bacterial respiratory tract infection in children(P<0.05).The area under the curve of the combination of the two indicators in the diagnosis of bacterial respiratory tract infection in children was 0.887(95%CI:0.741-0.975),the sensitivity was 90.91%,and the specificity was 80.00%.Conclusion sCD14-ST>443.82 pg/mL and IL-6>13.75 pg/mL are independent risk factors for bacterial respiratory tract infection in children.Combined detection of the two indicators can improve the diagnostic value of bacterial respiratory tract in
作者
杨洋
秦智彬
房丽云
YANG Yang;QIN Zhibin;FANG Liyun(Department of Pediatrics,the Affiliated Hospital of Northwest University/Xi′an Third Hospital,Xi′an,Shaanxi 710018,China)
出处
《检验医学与临床》
CAS
2024年第8期1130-1132,1136,共4页
Laboratory Medicine and Clinic
