摘要
目的 探究兰索拉唑联合奥曲肽治疗非静脉曲张性上消化道出血的临床效果。方法 以50例非静脉曲张性上消化道出血患者为对象,随机分成参照组及研究组,每组25例。参照组实施兰索拉唑治疗,研究组实施奥曲肽联合兰索拉唑治疗。比较两组患者的治疗效果,出血情况,血红蛋白水平,不良反应发生情况,生活质量。结果 研究组患者治疗有效率为100.00%,高于参照组的84.00%,差异显著(P<0.05)。研究组持续出血量(186.56±62.56)ml少于参照组的(312.67±112.56)ml、持续出血时间(11.45±4.56)h短于参照组的(21.35±5.67)h,差异显著(P<0.05)。治疗后,两组患者的血红蛋白水平均升高,且研究组血红蛋白水平(104.62±30.09)g/L高于参照组的(87.54±23.34)g/L,差异显著(P<0.05)。参照组患者不良反应发生率为8.00%,研究组患者不良反应发生率为4.00%,比较无明显差异(P>0.05)。治疗后,两组患者的生活质量评分均升高,且研究组生活质量评分(91.34±5.87)分高于参照组的(80.89±5.67)分,差异显著(P<0.05)。结论 非静脉曲张性上消化道出血患者实施奥曲肽联合兰索拉唑治疗,具有显著的治疗效果。
Objective To explore the clinical effect of lansoprazole combined with octreotide in the treatment of non-varicose upper gastrointestinal bleeding.Methods 50 patients with non-varicose upper gastrointestinal bleeding were randomly divided into a reference group and a study group,with 25 cases in each group.The reference group was treated with lansoprazole,and the study group was treated with octreotide and lansoprazole.The treatment effect,bleeding,hemoglobin level,occurrence of adverse reactions and quality of life were compared between the two groups.Results The effective rate of treatment in the study group was 100.00%,which was higher than 84.00%in the reference group,and the difference was significant(P<0.05).In the study group,the amount of sustained bleeding of(186.56±62.56)ml was less than(312.67±112.56)ml in the reference group,and the duration of sustained bleeding of(11.45±4.56)h was shorter than(21.35±5.67)h in the reference group.The difference was significant(P<0.05).After treatment,the hemoglobin level in both groups increased;the hemoglobin level of(104.62±30.09)g/L in the study group was higher than(87.54±23.34)g/L in the reference group;the difference was significant(P<0.05).The incidence of adverse reactions was 8.00%in the reference group and 4.00%in the study group,and the difference was not significant(P>0.05).After treatment,the quality of life score in both groups increased,and the quality of life score of(91.34±5.87)points in the study group was higher than(80.89±5.67)points in the reference group.The difference was significant(P<0.05).Conclusion The combination of octreotide and lansoprazole has a significant therapeutic effect on patients with non-varicose upper gastrointestinal bleeding.
作者
葛迎迎
GE Ying-ying(Second Department of Internal Medicine,Taishan District People's Hospital,Tai'an 271000,China)
出处
《中国实用医药》
2024年第6期99-102,共4页
China Practical Medicine
