摘要
目的探讨大柴胡汤加减联合复方嗜酸乳杆菌片治疗功能性便秘(FC)患者的临床疗效。方法根据随机数字表法将河南中医药大学第三附属医院2020年5月—2022年4月门诊治疗的70例FC患者随机分为两组,对照组(35例)服用复方嗜酸乳杆菌片治疗,治疗组联合大柴胡汤加减治疗。对比两组临床疗效、临床症状和便秘评分、胃肠道生活质量指数(GIQLI)、胃肠激素[P物质(SP)、胃动素(MTL)、胃泌素(GAS)]水平及不良反应。结果治疗组临床有效率(97.14%)高于对照组(80.00%)(P<0.05)。与治疗前相比,治疗后两组临床症状评分和便秘评分降低,胃肠激素水平和生活质量评分升高(P<0.05);与对照组相比,治疗组上述指标均优于对照组(P<0.05)。对照组与治疗组不良反应发生率(8.57%vs 5.71%)无统计学差异(P>0.05)。结论大柴胡汤加减联合复方嗜酸乳杆菌片治疗FC安全有效,且可减轻患者便秘症状,调节胃肠激素水平,提高生活质量。
Objective To explore the clinical efficacy of Modified Dachaihu Decoction(大柴胡汤加减)combined with Compound Lactobacillus Acidophilus Tablets in the treatment of functional constipation(FC).Methods From May 2020 to April 2022,a total of 70 patients with FC in the Third Affiliated Hospital of Henan University of Chinese Medicine were enrolled and divided into two groups according to the random number table method.The control group(35 cases)was given Compound Lactobacillus Acidophilus Tablets and the treatment group(35 cases)was given Modified Dachaihu Decoction additionally.The clinical efficacy,clinical symptom scores,constipation scores,gastrointestinal quality of life index(GIQLI)and the levels of gastrointestinal hormones[substance P(SP),motilin(MTL),gastrin(GAS)]and adverse reactions were compared between the two groups.Results The clinical effective rate in the treatment group was higher than that in control group(97.14%vs 80.00%)(P<0.05).After treatment,the symptom scores and constipation score decreased,the levels of gastrointestinal hormones and quality of life score increased in both groups(P<0.05).Compared with those in control group,the indexes mentioned-above were better in the treatment group(P<0.05).The incidence of adverse reactions between the two groups had no significant difference(8.57%vs 5.71%)(P>0.05).Conclusion Modified Dachaihu Decoction combined with Compound Lactobacillus Acidophilus Tablets is safe and effective for patients with FC,and could relieve the symptoms of constipation,adjust the levels of gastrointestinal hormones and improve the quality of life.
作者
冀二锋
杨会举
JI Erfeng;YANG Huiju(The Third Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450003,Henan,China)
出处
《辽宁中医杂志》
CAS
北大核心
2024年第4期95-98,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
河南省中医药拔尖人才项目(豫卫中医函[2021]15号)。
关键词
大柴胡汤加减
复方嗜酸乳杆菌片
功能性便秘
临床疗效
Modified Dachaihu Decoction(大柴胡汤加减)
Compound Lactobacillus Acidophilus Tablets
functional constipation
clinical efficacy
