摘要
目的研究门冬胰岛素联合地特胰岛素治疗妊娠期糖尿病的临床效果。方法抽取2019年3月至2021年2月南阳市第一人民医院收治的妊娠期糖尿病患者102例,按照随机数字表法分为单一组和联合组,每组51例。单一组采用门冬胰岛素治疗,联合组在单一组基础上采用地特胰岛素治疗。比较两组治疗效果、血糖达标时间,比较两组治疗前后血糖[空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)]水平、血清胆固醇(TC)、尿微量蛋白(mA1b)、总胆红素(TBil)水平,比较两组妊娠并发症发生率。结果联合组总有效率(94.12%,48/51)高于单一组(72.55%,37/51),P<0.05。联合组FPG达标时间、2hPG达标时间短于单一组(P<0.05)。治疗后,联合组FPG、2hPG、HbA1c水平低于单一组(P<0.05);治疗后,联合组TC、mA1b水平低于单一组,TBil水平高于单一组(P<0.05)。联合组妊娠并发症发生率(5.88%,3/51)低于单一组(23.53%,12/51),P<0.05。结论门冬胰岛素联合地特胰岛素方案治疗妊娠期糖尿病疗效显著,能快速改善患者血糖水平和血清生化指标,缩短血糖达标时间,降低产后低血糖、产后出血等妊娠并发症的发生。
Objective To study the clinical effect of insulin aspart combined with insulin detemir in the treatment of gestational diabetes.Methods A total of 102 patients with gestational diabetes treated in Nanyang First People’s Hospital from March 2019 to February 2021 were selected,and they were divided into single group and combined group according to random number table method,with 51 cases in each group.The single group was treated with insulin aspart,and the combined group was treated with insulin detemir based on the treatment of the single group.The curative effect and blood glucose standard time in the two groups were compared.The blood glucose level,including fasting plasma glucose(FPG),2-hour postprandial blood glucose(2hPG)and glycosylated hemoglobin(HbA1c),level of serum total cholesterol(TC),level of microprotein(mA1b)and level of total bilirubin(TBil)were compared between the two groups before and after treatment.The incidence of pregnancy complications were compared between the two groups.Results The total effective rate of the combined group(94.12%,48/51)was higher than that of the single group(72.55%,37/51),P<0.05.The FPG standard time and 2hPG standard time of the combined group were shorter than those of the single group(P<0.05).After treatment,the levels of FPG,2hPG and HbA1c in the combined group were lower than those in the single group(P<0.05).After treatment,the levels of TC and mA1b in the combined group were lower than those in the single group,and the level of TBil was higher than that in the single group(P<0.05).The incidence of pregnancy complications in the combined group(5.88%,3/51)was lower than that in the single group(23.53%,12/51),P<0.05.Conclusions Insulin aspart combined with insulin detemir has significant efficacy in the treatment of gestational diabetes,which can rapidly improve the blood glucose level and serum biochemical indexes,shorten the blood glucose standard time,and reduce the incidence of pregnancy complications,such as postpartum hypoglycemia and postpartum hemorrhage.
作者
姜克萍
王冉
张桂萍
Jiang Keping;Wang Ran;Zhang Guiping(Department of Obstetrics and Gynecology I,Nanyang First People's Hospital,Nanyang 473000,China)
出处
《中国实用医刊》
2024年第2期110-113,共4页
Chinese Journal of Practical Medicine
关键词
妊娠期糖尿病
门冬胰岛素
地特胰岛素
血糖
Diabetes,gestational
Insulin aspart
Insulin detemir
Blood glucose
