摘要
心血管疾病是导致我国居民死亡的首要原因。在2006—2019年间,我国每年因心血管疾病死亡的人数从215万人增加到328万人。斑马鱼因个体小、成本低廉、体外发育、身体透明、基因组与人类高度同源等特点,近年来被广泛应用于医学研究。斑马鱼模型有利于推动心血管疾病领域的基础性研究。该文通过对前期研究进行综述,重点介绍了斑马鱼模型在心血管疾病中基因筛选、心脏再生、药物筛选、毒性评估等方面的研究进展。
Cardiovascular disease is the leading cause of death in China.Between 2006 and 2019,the annual number of deaths due to cardiovascular diseases increased from 2.15 million to 3.28 million.Zebrafish has been widely used in medical research in recent years because of its small individual size,low cost,in vitro development,transparent body and high homology of genome with human.The zebrafish model is conducive to promoting basic research in the field of cardiovascular disease.Based on the review of previous studies,this paper focuses on the research progress of zebrafish model in gene screening,cardiac regeneration,drug screening,toxicity assessment and other aspects of cardiovascular diseases.
作者
董顺雨
张态
DONG Shunyu;ZHANG Tai(School of Public Health,Dali University,Dali 671000,China)
出处
《广州医药》
2024年第3期231-235,共5页
Guangzhou Medical Journal
基金
中国西南药用昆虫及蛛形类资源开发利用协同创新中心(CIC1803)。
关键词
斑马鱼
心血管疾病
心脏再生
药物筛选
毒性评估
zebrafish
cardiovascular disease
heart regeneration
drug screening
toxicity assessment
