摘要
目的探讨超声二维灰阶血流显像技术(B-Flow)联合外周血中性粒细胞与淋巴细胞比值(NLR)、C反应蛋白(CRP)诊断颈动脉粥样硬化(CAS)斑块易损性的价值。方法纳入2019年2月至2022年8月在天津市永久医院诊查的152例CAS患者为研究对象,均利用颈动脉斑块超声B-Flow和数字减影血管造影(DSA)检查斑块性质,并检测外周血NLR、CRP水平,以DSA结果为“金标准”,将患者分为易损斑块组和稳定斑块组,统计超声B-Flow检查结果,比较两组外周血NLR、CRP水平,分析超声B-Flow、外周血NLR、CRP水平三者单独及联合诊断CAS斑块易损性的价值。结果DSA检查结果显示,152例CAS患者检出66例易损斑块,86例为稳定斑块;超声B-Flow检查出72例易损斑块,80例稳定斑块,以DSA检查结果作为“金标准”,超声B-Flow诊断易损斑块的灵敏度、特异度、准确度分别为84.85%、81.39%、82.89%;易损斑块组外周血NLR、CRP水平均高于稳定斑块组(P<0.05);超声B-Flow联合外周血NLR、CRP水平诊断CAS易损性斑块的灵敏度、特异度、曲线下面积(AUC)分别为98.48、81.39%、0.907,联合诊断的灵敏度高于单独诊断,AUC高于单独诊断(P<0.05),特异度与单独诊断相近。结论超声B-Flow、外周血NLR、CRP均对CAS斑块易损性具有一定的诊断效能,但三者联合诊断效能更好。
Objective To investigate the diagnostic efficacy of ultrasound two-dimensional gray scale blood flow imaging(B-Flow)combined with peripheral blood neutrophil lymphocyte ratio(NLR)and C-reactive protein(CRP)in the diagnosis of carotid atherosclerosis(CAS)plaque vulnerability.Methods 152 CAS patients diagnosed at Tianjin Permanent Hospital from February 2019 to August 2022 were selected as the study subjects.Carotid plaque ultrasound B-Flow and digital subtraction angiography(DSA)were used to examine the plaque properties,and peripheral blood NLR and CRP levels were detected.The DSA results were us as the“gold standard”,and the patients were divided into vulnerable plaque group and stable plaque group according to the nature of plaque.The results of ultrasound B-Flow examination were statistically analyzed,and the levels of peripheral blood NLR and CRP were compared between the two groups.The value of ultrasound B-Flow,peripheral blood NLR and CRP levels alone and in combination in the diagnosis of CAS plaque vulnerability was analyzed.Results DSA examination showed that 66 of 152 patients with carotid atherosclerosis were vulnerable plaque and 86 were stable plaque.Ultrasound B-Flow detected 72 cases of vulnerable plaques and 80 cases of stable plaques,and the sensitivity,specificity and accuracy of ultrasound B-Flow in diagnosing vulnerable plaques were 84.85%,81.39% and 82.89%,with the DSA examination results as the"gold standard".The levels of NLR and CRP in peripheral blood of vulnerable plaque group were higher than those of stable plaque group(P<0.05).The sensitivity,specificity and area under the curve(AUC)of ultrasound B-Flow combined with peripheral blood NLR and CRP levels in the diagnosis of vulnerable plaque of carotid atherosclerosis were 98.48,81.39% and 0.907,respectively,and the sensitivity of joint diagnosis was higher than that of individual diagnosis,and the AUC was higher than that of individual diagnosis(P<0.05),but the specificity was similar to that of individual diagnosis.Conclusion Ult
作者
李亮亮
LI Liang-liang(Ultrasound Department of Tianjin Permanent Hospital,Tianjin 300450,China)
出处
《罕少疾病杂志》
2024年第4期21-23,共3页
Journal of Rare and Uncommon Diseases
关键词
颈动脉粥样硬化
超声二维灰阶血流显像技术
中性粒细胞
淋巴细胞
C反应蛋白
易损斑块
Carotid Atherosclerosis
Ultrasound Two-dimensional Gray Scale Blood Flow Imaging Technology
Neutrophils
Lymphocytes
C-reactive Protein
Vulnerable Plaque
